Abstract
Alzheimers disease (AD) is an age-related neurodegenerative disorder that is characterized by a progressive loss in memory and deterioration of the higher cognitive functions. The brain of an individual with AD exhibits extracellular senile plaques of aggregated amyloid-beta-peptide (Aβ), intracellular neurofibrillary tangles (NFTs) that consist of hyperphosphorylated tau protein (P-tau) and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. Recent data obtained via genomics, proteomics and molecular genetics, have gleaned new information with regard to the physiological and pathophysiological functions of the amyloid precursor protein (APP) and its cleavage product Aβ. This review glances over several aspects that may play a major role in the pathogenesis of AD providing an insight into APPs and Aβs interplay with other cellular systems.
Keywords: Alzheimer's disease, apoptosis, cell death, neurodegeneration
Current Alzheimer Research
Title: Alzheimers Disease - An Interactive Perspective
Volume: 3 Issue: 2
Author(s): Klaus Heese and Hiroyasu Akatsu
Affiliation:
Keywords: Alzheimer's disease, apoptosis, cell death, neurodegeneration
Abstract: Alzheimers disease (AD) is an age-related neurodegenerative disorder that is characterized by a progressive loss in memory and deterioration of the higher cognitive functions. The brain of an individual with AD exhibits extracellular senile plaques of aggregated amyloid-beta-peptide (Aβ), intracellular neurofibrillary tangles (NFTs) that consist of hyperphosphorylated tau protein (P-tau) and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. Recent data obtained via genomics, proteomics and molecular genetics, have gleaned new information with regard to the physiological and pathophysiological functions of the amyloid precursor protein (APP) and its cleavage product Aβ. This review glances over several aspects that may play a major role in the pathogenesis of AD providing an insight into APPs and Aβs interplay with other cellular systems.
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Cite this article as:
Heese Klaus and Akatsu Hiroyasu, Alzheimers Disease - An Interactive Perspective, Current Alzheimer Research 2006; 3 (2) . https://dx.doi.org/10.2174/156720506776383022
DOI https://dx.doi.org/10.2174/156720506776383022 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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