Abstract
Some new 4β-N-heteroaryl analogues of podophyllotoxin have been prepared by employing Red Phosphorous/I2 reagent system. These 4β-N-heteroaryl analogues have been evaluated for their cytotoxicity against six human cancer cell lines and some representative ones have shown promising anticancer activity.
Keywords: Epipodophyllotoxin, benzothiazoles, pyrimidines, anticancer activity
Letters in Drug Design & Discovery
Title: Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin
Volume: 3 Issue: 3
Author(s): Ahmed Kamal, B. A. Kumar, M. Arifuddin and Sunanda G. Dastidar
Affiliation:
Keywords: Epipodophyllotoxin, benzothiazoles, pyrimidines, anticancer activity
Abstract: Some new 4β-N-heteroaryl analogues of podophyllotoxin have been prepared by employing Red Phosphorous/I2 reagent system. These 4β-N-heteroaryl analogues have been evaluated for their cytotoxicity against six human cancer cell lines and some representative ones have shown promising anticancer activity.
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Cite this article as:
Kamal Ahmed, Kumar A. B., Arifuddin M. and Dastidar G. Sunanda, Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin, Letters in Drug Design & Discovery 2006; 3 (3) . https://dx.doi.org/10.2174/157018006776286907
DOI https://dx.doi.org/10.2174/157018006776286907 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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