Abstract
CD38, a 45-kDa cell surface glycoprotein, is involved in the synthesis of the calcium mobilizing second messenger molecule cyclic ADP-ribose. Cyclic ADP-ribose is known to release calcium from the sarcoplasmic reticulum of airway smooth muscle cells. The pharmacological features of cyclic ADP-ribose-mediated calcium release in airway smooth muscle cells are distinct from those mediated by inositol 1,4,5-trisphosphate and involve activation of ryanodine receptor channels. In airway smooth muscle cells, contractile agonists recruit cyclic ADP-ribose for intracellular calcium release in a receptor- and receptor-subtype-specific fashion. The CD38/cyclic ADP-ribose signaling has a role in airway function, since methacholine-induced airway resistance is significantly lower in CD38 deficient mice than in the wild type controls. The diminished airway responsiveness appears to result from lower intracellular calcium responses to spasmogens. In human airway smooth muscle cells, inflammatory and Th-2 cytokines increase the expression of CD38 and augment the capacity for cyclic ADP-ribose-mediated calcium release during agonist stimulation. These results suggest a role for cyclic ADP-ribose in airway smooth muscle hyperresponsiveness during inflammation. This review will focus on the role of CD38 and cyclic ADP-ribose in normal airway function and its potential contribution to airway hyperresponsiveness in inflammatory diseases such as asthma.
Keywords: Cyclic ADP-ribose, airway smooth muscle, calcium, cytokines, asthma
Current Respiratory Medicine Reviews
Title: Role of CD38 in Airway Function
Volume: 2 Issue: 2
Author(s): Bit Na Kang, Alonso G.P. Guedes, K. G. Tirumurugaan, Joseph A. Jude, Deepak A. Deshpande, Reynold A. Panettieri, Yassine Amrani, Frances E. Lund, Timothy F. Walseth and Mathur S. Kannan
Affiliation:
Keywords: Cyclic ADP-ribose, airway smooth muscle, calcium, cytokines, asthma
Abstract: CD38, a 45-kDa cell surface glycoprotein, is involved in the synthesis of the calcium mobilizing second messenger molecule cyclic ADP-ribose. Cyclic ADP-ribose is known to release calcium from the sarcoplasmic reticulum of airway smooth muscle cells. The pharmacological features of cyclic ADP-ribose-mediated calcium release in airway smooth muscle cells are distinct from those mediated by inositol 1,4,5-trisphosphate and involve activation of ryanodine receptor channels. In airway smooth muscle cells, contractile agonists recruit cyclic ADP-ribose for intracellular calcium release in a receptor- and receptor-subtype-specific fashion. The CD38/cyclic ADP-ribose signaling has a role in airway function, since methacholine-induced airway resistance is significantly lower in CD38 deficient mice than in the wild type controls. The diminished airway responsiveness appears to result from lower intracellular calcium responses to spasmogens. In human airway smooth muscle cells, inflammatory and Th-2 cytokines increase the expression of CD38 and augment the capacity for cyclic ADP-ribose-mediated calcium release during agonist stimulation. These results suggest a role for cyclic ADP-ribose in airway smooth muscle hyperresponsiveness during inflammation. This review will focus on the role of CD38 and cyclic ADP-ribose in normal airway function and its potential contribution to airway hyperresponsiveness in inflammatory diseases such as asthma.
Export Options
About this article
Cite this article as:
Kang Na Bit, Guedes G.P. Alonso, Tirumurugaan G. K., Jude A. Joseph, Deshpande A. Deepak, Panettieri A. Reynold, Amrani Yassine, Lund E. Frances, Walseth F. Timothy and Kannan S. Mathur, Role of CD38 in Airway Function, Current Respiratory Medicine Reviews 2006; 2 (2) . https://dx.doi.org/10.2174/157339806776843058
DOI https://dx.doi.org/10.2174/157339806776843058 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biomarkers Linking PCB Exposure and Obesity
Current Pharmaceutical Biotechnology Development of Trypsin-Like Serine Protease Inhibitors as Therapeutic Agents: Opportunities, Challenges, and their Unique Structure-Based Rationales
Current Topics in Medicinal Chemistry Neuromodulatory and Anti-Inflammatory Ingredient for Sensitive Skin: In Vitro Assessment
Inflammation & Allergy - Drug Targets (Discontinued) Current Issues in Pharmaceutical Residues in Drinking Water
Current Analytical Chemistry Pro- and Anti-Arrhythmic Effects of Anti-Inflammatory Drugs
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Medicinal Chemistry and Therapeutic Potential of Agonists, Antagonists and Allosteric Modulators of A1 Adenosine Receptor: Current Status and Perspectives
Current Pharmaceutical Design Does Pharmacological Therapy Still Play a Role in Preventing Sudden Death in Surgically Treated Tetralogy of Fallot?
Mini-Reviews in Medicinal Chemistry Rhinosinusitis in the Pediatric Patient with Cystic Fibrosis
Current Pediatric Reviews Immunomodulatory Effects of Soybeans and Processed Soy Food Compounds
Recent Patents on Food, Nutrition & Agriculture Analysis of Chinese Herbal Formulae Recommended for COVID-19 in Different Schemes in China: A Data Mining Approach
Combinatorial Chemistry & High Throughput Screening Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery Chlorine, Chlorination By-Products and Their Allergic and Respiratory Health Effects
Current Respiratory Medicine Reviews Mitochondrial Biogenesis: Regulation By Endogenous Gases During Inflammation and Organ Stress
Current Pharmaceutical Design Cross-talk of Signaling Pathways in the Pathogenesis of Allergic Asthma and Cataract
Protein & Peptide Letters Cholinergic Drugs as Therapeutic Tools in Inflammatory Diseases: Participation of Neuronal and Non-Neuronal Cholinergic Systems.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Evidence and the Main Adverse Effects Regarding Drug Therapies in the War Against COVID-19
Current Medicinal Chemistry An Augmented Passive Immune Therapy to Treat Fulminant Bacterial Infections
Recent Patents on Anti-Infective Drug Discovery Leukocyte Adhesion: A Suitable Target for Anti-Inflammatory Drugs
Current Pharmaceutical Design Inflammatory Cytokines, Growth Factors, and Depression
Current Pharmaceutical Design Biomarker Metabolite Signatures Pave the Way for Electronic-nose Applications in Early Clinical Disease Diagnoses
Current Metabolomics