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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Myostatin: Biology and Clinical Relevance

Author(s): Gilles Carnac, Stephanie Ricaud, Barbara Vernus and Anne Bonnieu

Volume 6, Issue 7, 2006

Page: [765 - 770] Pages: 6

DOI: 10.2174/138955706777698642

Price: $65

Abstract

Myostatin is a negative regulator of muscle mass. Important advances in our understanding of thecomplex biology of this factor have revealed the therapeutic potential of antagonizing the myostatin pathway. Herewe present the rationale for evaluating anti-myostatin therapies in human muscle-wasting disorders.

Keywords: Myostatin, Muscle, Adipose tissue, Rhabdomyosarcoma, Myostatin antagonism, Myostatin processing and signaling, therapeutic approaches


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