Abstract
Integrins are composed of a variety of binding subunits that are responsible for interacting with the extracellu-lar matrix and intracellular signaling pathways. Among their various functions, integrins have the ability to augment cellu-lar adhesion, influence cytoskeletal architecture, activate tyrosine kinase and affect cell survival. Many investigations have demonstrated a correlation between the regulation of integrin expression and tumor invasiveness and proliferation. Integrins affect transcription factors Twist and HoxD3, epigenetic regulation, matrix metalloproteinases, insulin-like growth factors, integrin-linked kinases and adherens junctions, which are all important components of tumorigenicity. Cancer cells modify their functional genomic composition thereby altering integrin expression. Understanding the rela-tionship between integrin expression and tumor activities could provide an important strategy for cancer treatment.
Keywords: Integrin, cancer, Twist, ILK, MMP, epigenetic, HoxD3
Current Genomics
Title: Integrins and Cancer: Gene Expression, Epigenetics and Metastasis
Volume: 7 Issue: 5
Author(s): T. Stuardi, S. M.O. Phipps and T. O. Tollefsbol
Affiliation:
Keywords: Integrin, cancer, Twist, ILK, MMP, epigenetic, HoxD3
Abstract: Integrins are composed of a variety of binding subunits that are responsible for interacting with the extracellu-lar matrix and intracellular signaling pathways. Among their various functions, integrins have the ability to augment cellu-lar adhesion, influence cytoskeletal architecture, activate tyrosine kinase and affect cell survival. Many investigations have demonstrated a correlation between the regulation of integrin expression and tumor invasiveness and proliferation. Integrins affect transcription factors Twist and HoxD3, epigenetic regulation, matrix metalloproteinases, insulin-like growth factors, integrin-linked kinases and adherens junctions, which are all important components of tumorigenicity. Cancer cells modify their functional genomic composition thereby altering integrin expression. Understanding the rela-tionship between integrin expression and tumor activities could provide an important strategy for cancer treatment.
Export Options
About this article
Cite this article as:
Stuardi T., M.O. Phipps S. and O. Tollefsbol T., Integrins and Cancer: Gene Expression, Epigenetics and Metastasis, Current Genomics 2006; 7 (5) . https://dx.doi.org/10.2174/138920206778604377
DOI https://dx.doi.org/10.2174/138920206778604377 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Peptides in Oral Diseases
Current Pharmaceutical Design What they are, How they Work and Why they do What they do? The Story of SV40-derived Gene Therapy Vectors and What They Have to Offer
Current Gene Therapy Design and Synthesis of Curcumin-Like Diarylpentanoid Analogues as Potential Anticancer Agents
Recent Patents on Anti-Cancer Drug Discovery Novel Implications for Lysophospholipids, Lysophosphatidic Acid and Sphingosine 1-Phosphate, as Drug Targets in Cancer
Anti-Cancer Agents in Medicinal Chemistry What are the Cancer Risks in BRCA Carriers Apart from Those Regarding the Breast and the Ovary?
Current Women`s Health Reviews Benzothiazole: A Versatile and Multitargeted Pharmacophore in the Field of Medicinal Chemistry
Letters in Organic Chemistry Screening of Significant Biomarkers Related to Prognosis of Cervical Cancer and Functional Study Based on lncRNA-associated ceRNA Regulatory Network
Combinatorial Chemistry & High Throughput Screening Recent Advances in Designing Substrate-Competitive Protein Kinase Inhibitors
Current Pharmaceutical Design Thiourea and Guanidine Derivatives as Antimalarial and Antimicrobial Agents<sup>§</sup>
Current Topics in Medicinal Chemistry Synthetic Lethality and PARP-Inhibitors in Oral and Head & Neck Cancer
Current Pharmaceutical Design Evidence-Based Management of Infertile Couples with Repeated Implantation Failure Following IVF
Current Women`s Health Reviews Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase
Medicinal Chemistry Stereotactic Body Radiotherapy in the Management of Head and Neck Malignancies
Current Cancer Therapy Reviews Application of a Deep Matrix Factorization Model on Integrated Gene Expression Data
Current Bioinformatics Peptides to Target Tumor Vasculature and Lymphatics for Improved Anti-Angiogenesis Therapy
Current Cancer Drug Targets Pleiotropic Role of HSF1 in Neoplastic Transformation
Current Cancer Drug Targets A General Method for the Synthesis of 3,3-bis(indol-3-yl)indolin-2-ones, bis(indol-3-yl)(aryl)methanes and tris(indol-3-yl)methanes Using Naturally Occurring Mandelic Acid as an Efficient Organo-catalyst in Aqueous Ethanol at Room Temperature
Current Green Chemistry Sonoelastography for Pelvic Metastatic Malignant Pheochromocytoma: A Case Report
Current Medical Imaging Potential Benefits of Glitazones for Cancer and Vascular Disease
Current Drug Therapy An Insight into Drug Repositioning for the Development of Novel Anti-Cancer Drugs
Current Topics in Medicinal Chemistry