Abstract
The use of dopamine agonists has increased due to their effectiveness in treating symptoms of Parkinson disease (PD) and Restless Leg Syndrome (RLS). Recently, rare but serious adverse effects have been linked to DA agonists, including sudden somnolence, cardiac valvulopathy and repetitive behaviors. Clinicians are in a difficult situation because of insufficient information to make clear recommendations to patients. We review these controversies, discuss pathophysiology and report current practices in light of such uncertainty.
Keywords: Dopamine agonists, adverse effects, sleep attacks, valvulopathy, punding, dopamine dysregulation syndrome
Current Drug Therapy
Title: Controversies of Dopamine Agonists: Somnolence, Cardiac Valvulopathy and Repetitive Behaviors
Volume: 2 Issue: 1
Author(s): Samay Jain and Cheryl H. Waters
Affiliation:
Keywords: Dopamine agonists, adverse effects, sleep attacks, valvulopathy, punding, dopamine dysregulation syndrome
Abstract: The use of dopamine agonists has increased due to their effectiveness in treating symptoms of Parkinson disease (PD) and Restless Leg Syndrome (RLS). Recently, rare but serious adverse effects have been linked to DA agonists, including sudden somnolence, cardiac valvulopathy and repetitive behaviors. Clinicians are in a difficult situation because of insufficient information to make clear recommendations to patients. We review these controversies, discuss pathophysiology and report current practices in light of such uncertainty.
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Cite this article as:
Jain Samay and Waters H. Cheryl, Controversies of Dopamine Agonists: Somnolence, Cardiac Valvulopathy and Repetitive Behaviors, Current Drug Therapy 2007; 2 (1) . https://dx.doi.org/10.2174/157488507779422347
DOI https://dx.doi.org/10.2174/157488507779422347 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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