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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Indoleamine 2,3-Dioxygenase in Materno-Fetal Interaction

Author(s): Peter Sedlmayr

Volume 8, Issue 3, 2007

Page: [205 - 208] Pages: 4

DOI: 10.2174/138920007780362491

Price: $65

Abstract

The mechanism of maternal immunotolerance of the semiallogeneic fetus has been a matter of intense investigation. The tryptophan- degrading enzyme indoleamine 2,3-dioxygenase (IDO) is reported to be critically implicated. This article discusses findings pertaining to the role of IDO in pregnancy, its location at the feto-maternal interface, systemic induction of IDO in pregnancy and the association of IDO to spontaneous abortion and preeclampsia. Whereas there is a large body of evidence supporting the relevance of IDO as a key immunoregulatory factor in feto-maternal tolerance, open questions remain concerning as to its role.

Keywords: Feto-maternal tolerance, tryptophan catabolism, placenta, trophoblast, decidua, preeclampsia, spontaneous abortion


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