Abstract
The angiotensin converting enzyme (ACE) I/D polymorphism has been one of the most studied genetic systems. It comprises hundreds of reports and a myriad of disease associations, including cardiovascular, metabolic, immune, cancer, aging, neurodegenerative and psychiatric diseases. Despite the wealth of information on the ACE polymorphism and the well-known functions of ACE, several questions arise. Why does the ACE polymorphism associate with so many diseases? What is its function? In this review, we summarize the current information on the ACE polymorphism and explain its function in the context of cell survival. We also provide a model to understand its role in biology and disease at the organism and population levels.
Keywords: cell survival, stem cells, vasculature, regeneration, aging, alu, mobile elements
Current Pharmaceutical Design
Title: Demystifying the ACE Polymorphism: From Genetics to Biology
Volume: 13 Issue: 12
Author(s): Raquel Castellon and Hamdi K. Hamdi
Affiliation:
Keywords: cell survival, stem cells, vasculature, regeneration, aging, alu, mobile elements
Abstract: The angiotensin converting enzyme (ACE) I/D polymorphism has been one of the most studied genetic systems. It comprises hundreds of reports and a myriad of disease associations, including cardiovascular, metabolic, immune, cancer, aging, neurodegenerative and psychiatric diseases. Despite the wealth of information on the ACE polymorphism and the well-known functions of ACE, several questions arise. Why does the ACE polymorphism associate with so many diseases? What is its function? In this review, we summarize the current information on the ACE polymorphism and explain its function in the context of cell survival. We also provide a model to understand its role in biology and disease at the organism and population levels.
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Cite this article as:
Castellon Raquel and Hamdi K. Hamdi, Demystifying the ACE Polymorphism: From Genetics to Biology, Current Pharmaceutical Design 2007; 13 (12) . https://dx.doi.org/10.2174/138161207780618902
DOI https://dx.doi.org/10.2174/138161207780618902 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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