Abstract
The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.
Keywords: Fra-1, Jun, TAM67, tumor promotion, invasion, inflammation
Current Cancer Drug Targets
Title: AP-1 a Target for Cancer Prevention
Volume: 7 Issue: 4
Author(s): Connie P. Matthews, Nancy H. Colburn and Matthew R. Young
Affiliation:
Keywords: Fra-1, Jun, TAM67, tumor promotion, invasion, inflammation
Abstract: The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.
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Cite this article as:
Matthews P. Connie, Colburn H. Nancy and Young R. Matthew, AP-1 a Target for Cancer Prevention, Current Cancer Drug Targets 2007; 7 (4) . https://dx.doi.org/10.2174/156800907780809723
DOI https://dx.doi.org/10.2174/156800907780809723 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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