Abstract
In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimers disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acetylcholinesterase treatment to multiple mechanisms-based therapy targeting amyloid plaques formation and amyloid peptides (Aβ)-mediated cytotoxicity, and neurofibrillary tangles generation. This review will cover current experimental studies with the focus on secretases-based drug development, immunotherapy, and anti-neurofibrillary tangles intervention. The outcome of these on-going studies may provide high hope that AD can be cured in the future.
Keywords: Experimental approach, Alzheimer's disease, secretase, amyloid plaque, neurofibrillary tangles, immunotherapy, small interfering molecule, gene therapy
Current Neuropharmacology
Title: Current Experimental Therapy for Alzheimers Disease
Volume: 5 Issue: 2
Author(s): Sheng Chen, Xiao-Jie Zhang, Liang Li and Wei-Dong Le
Affiliation:
Keywords: Experimental approach, Alzheimer's disease, secretase, amyloid plaque, neurofibrillary tangles, immunotherapy, small interfering molecule, gene therapy
Abstract: In the past decade, enormous efforts have been devoted to understand the genetics and molecular pathogenesis of Alzheimers disease (AD), which has been transferred into extensive experimental approaches aimed at reversing disease progression. The trend in future AD therapy has been shifted from traditional anti-acetylcholinesterase treatment to multiple mechanisms-based therapy targeting amyloid plaques formation and amyloid peptides (Aβ)-mediated cytotoxicity, and neurofibrillary tangles generation. This review will cover current experimental studies with the focus on secretases-based drug development, immunotherapy, and anti-neurofibrillary tangles intervention. The outcome of these on-going studies may provide high hope that AD can be cured in the future.
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Cite this article as:
Chen Sheng, Zhang Xiao-Jie, Li Liang and Le Wei-Dong, Current Experimental Therapy for Alzheimers Disease, Current Neuropharmacology 2007; 5 (2) . https://dx.doi.org/10.2174/157015907780866901
DOI https://dx.doi.org/10.2174/157015907780866901 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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