Abstract
With the alarming increase in the incidence of diabetes mellitus worldwide, there is a growing need to develop new strategies to control hyperglycemia. Currently available treatments cause various adverse effects and do not necessarily achieve optimal glycemic control. Recently, peptides that may ameliorate the symptoms of diabetes mellitus have been investigated extensively and show great promise. Synthetic analogs of amylin and incretin mimetics may be ideal adjuncts to diabetes therapy. Amylin analogs significantly improve postprandial control in patients with either type 1 or type 2 diabetes without an increased risk of hypoglycemia or weight gain. Incretin mimetics are a new option for patients suffering from type 2 diabetes and are being considered as a stand-alone therapy. The present paper reviews novel peptides as potential agents for glucose control and prevention of the complications associated with diabetes.
Keywords: Diabetes mellitus, peptides, alternatives
Current Drug Therapy
Title: Novel Peptides: An Alternative Approach for the Treatment of Diabetes Mellitus
Volume: 2 Issue: 3
Author(s): Rumi Ghosh, Vaidehi Thanawala and Vilasrao J. Kadam
Affiliation:
Keywords: Diabetes mellitus, peptides, alternatives
Abstract: With the alarming increase in the incidence of diabetes mellitus worldwide, there is a growing need to develop new strategies to control hyperglycemia. Currently available treatments cause various adverse effects and do not necessarily achieve optimal glycemic control. Recently, peptides that may ameliorate the symptoms of diabetes mellitus have been investigated extensively and show great promise. Synthetic analogs of amylin and incretin mimetics may be ideal adjuncts to diabetes therapy. Amylin analogs significantly improve postprandial control in patients with either type 1 or type 2 diabetes without an increased risk of hypoglycemia or weight gain. Incretin mimetics are a new option for patients suffering from type 2 diabetes and are being considered as a stand-alone therapy. The present paper reviews novel peptides as potential agents for glucose control and prevention of the complications associated with diabetes.
Export Options
About this article
Cite this article as:
Ghosh Rumi, Thanawala Vaidehi and Kadam J. Vilasrao, Novel Peptides: An Alternative Approach for the Treatment of Diabetes Mellitus, Current Drug Therapy 2007; 2 (3) . https://dx.doi.org/10.2174/157488507781695658
DOI https://dx.doi.org/10.2174/157488507781695658 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Intratubular Renin-Angiotensin System in Hypertension
Current Hypertension Reviews Cardiovascular Effects of Omega-3 Free Fatty Acids.
Current Vascular Pharmacology The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative Diseases
Recent Patents on CNS Drug Discovery (Discontinued) Editorial [Hot topic: Vitamin D Deficiency in Cardiovascular and Renal Disease: New Light Shed on an Old Enemy (Guest Editor: Martin H. de Borst)]
Current Drug Targets High Throughput Screening for Drug Discovery of Autophagy Modulators
Combinatorial Chemistry & High Throughput Screening Fibrinolysis: The Key to New Pathogenetic Mechanisms
Current Medicinal Chemistry Amyloid Forming Proteases: Therapeutic Targets for Alzheimers Disease
Current Pharmaceutical Design Olive Oil and Haemostasis: Platelet Function, Thrombogenesis and Fibrinolysis
Current Pharmaceutical Design CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes
Current Drug Targets The Heart in Sepsis: From Basic Mechanisms to Clinical Management
Current Vascular Pharmacology Epidural Steroid Injections Do Not Induce Weight Gain
Current Drug Safety A Review on Experimental Methods for Diabetes Induction and Therapeutic Efficacy of Anti-diabetic Drug Loaded Nanoformulation
Current Drug Therapy Potential of Plant Mucilages in Pharmaceuticals and Therapy
Current Drug Delivery Breastfeeding Policy Development and the Prevention of Obesity
Current Pediatric Reviews Effects of Synthetic Peptides on the Inflammatory Response and their Therapeutic Potential
Mini-Reviews in Medicinal Chemistry Bariatric Surgery: Indications, Safety and Efficacy
Current Pharmaceutical Design The Role of Parathyroid Hormone-Related Protein (PTHrP) in the Pathophysiology of Diabetes Mellitus
Mini-Reviews in Medicinal Chemistry Visceral Adipose Tissue and Atherosclerosis
Current Vascular Pharmacology Metabolic Adaptations to Pregnancy in Healthy and Gestational Diabetic Pregnancies: The Pancreas - Placenta Axis
Current Vascular Pharmacology Baru Nut Intake and Resistance Training Practice have Potential to Reduce the Cardiometabolic Risk Factors in Type 2 Diabetes
Current Nutrition & Food Science