Abstract
Cubilin and megalin are multiligand receptors that mediate uptake of extracellular ligands. Their function has extensively been studied in the kidney where they play a key role in vitamin B12 and vitamin D homeostasis. Amnionless is a plasma membrane protein that binds to cubilin in various epithelia; the interaction cubilin-amnionless in the gut is crucial for dietary vitamin B12 uptake. Studies in patients with gene defects in these receptors, and animal models with inactivated cubilin, megalin or amnionless suggest an important role in embryonic development and normal growth. In this review we will summarize recent data on the biological function of these receptors and focus on their implication in embryonic nutrition and central nervous system malformations.
Keywords: Cubilin, megalin, amnionless, neural tube defects, endocytosis
Current Pharmaceutical Design
Title: Multiligand Endocytosis and Congenital Defects: Roles of Cubilin, Megalin and Amnionless
Volume: 13 Issue: 29
Author(s): Renata Kozyraki and Francoise Gofflot
Affiliation:
Keywords: Cubilin, megalin, amnionless, neural tube defects, endocytosis
Abstract: Cubilin and megalin are multiligand receptors that mediate uptake of extracellular ligands. Their function has extensively been studied in the kidney where they play a key role in vitamin B12 and vitamin D homeostasis. Amnionless is a plasma membrane protein that binds to cubilin in various epithelia; the interaction cubilin-amnionless in the gut is crucial for dietary vitamin B12 uptake. Studies in patients with gene defects in these receptors, and animal models with inactivated cubilin, megalin or amnionless suggest an important role in embryonic development and normal growth. In this review we will summarize recent data on the biological function of these receptors and focus on their implication in embryonic nutrition and central nervous system malformations.
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Cite this article as:
Kozyraki Renata and Gofflot Francoise, Multiligand Endocytosis and Congenital Defects: Roles of Cubilin, Megalin and Amnionless, Current Pharmaceutical Design 2007; 13 (29) . https://dx.doi.org/10.2174/138161207782110507
DOI https://dx.doi.org/10.2174/138161207782110507 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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