Abstract
As inductive tissues for the initiation of antigen-specific T and B cell responses, the various mucosa-associated lymphoid tissues (MALT) of the aerodigestive tract, which include gut-associated lymphoid tissue (GALT), nasopharynx-associated lymphoid tissue (NALT) and bronchus-associated lymphoid tissue (BALT), share many histological and immunological characteristics. However, recent advances in our molecular and cellular understanding of immunological development have revealed that the various types of MALT also exhibit different molecular and cellular interactions for their organogenesis. In this review, we delineate the distinctive features of GALT, NALT and BALT and seek to show the role played by those features in the regulation of mucosal tissue organogenesis, the mucosal immune system, and mucosal homeostasis, all in an attempt to provide insights which might lead to a prospective mucosal vaccine.
Keywords: gut-associated lymphoid tissue, nasopharynx-associated lymphoid tissue, bronchus-associated lymphoid tissue, peyers patches, isolated lymphoid follicles, dendritic cells, tumor necrosis factor, epithelial cells, organogenesis, mucosal vaccine
Current Molecular Medicine
Title: Mucosa-Associated Lymphoid Tissues in the Aerodigestive Tract: Their Shared and Divergent Traits and Their Importance to the Orchestration of the Mucosal Immune System
Volume: 5 Issue: 6
Author(s): Jun Kunisawa, Satoshi Fukuyama and Hiroshi Kiyono
Affiliation:
Keywords: gut-associated lymphoid tissue, nasopharynx-associated lymphoid tissue, bronchus-associated lymphoid tissue, peyers patches, isolated lymphoid follicles, dendritic cells, tumor necrosis factor, epithelial cells, organogenesis, mucosal vaccine
Abstract: As inductive tissues for the initiation of antigen-specific T and B cell responses, the various mucosa-associated lymphoid tissues (MALT) of the aerodigestive tract, which include gut-associated lymphoid tissue (GALT), nasopharynx-associated lymphoid tissue (NALT) and bronchus-associated lymphoid tissue (BALT), share many histological and immunological characteristics. However, recent advances in our molecular and cellular understanding of immunological development have revealed that the various types of MALT also exhibit different molecular and cellular interactions for their organogenesis. In this review, we delineate the distinctive features of GALT, NALT and BALT and seek to show the role played by those features in the regulation of mucosal tissue organogenesis, the mucosal immune system, and mucosal homeostasis, all in an attempt to provide insights which might lead to a prospective mucosal vaccine.
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Cite this article as:
Kunisawa Jun, Fukuyama Satoshi and Kiyono Hiroshi, Mucosa-Associated Lymphoid Tissues in the Aerodigestive Tract: Their Shared and Divergent Traits and Their Importance to the Orchestration of the Mucosal Immune System, Current Molecular Medicine 2005; 5 (6) . https://dx.doi.org/10.2174/1566524054863924
DOI https://dx.doi.org/10.2174/1566524054863924 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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