Abstract
It is well recognised that the Major Histocompatibility Complex (MHC) harbours the main psoriasis susceptibility locus (PSORS1, Psoriasis Susceptibility 1). Nonetheless, linkage analyses have repeatedly shown that the PSORS1 locus account for less than 50% of the disease family clustering. On this basis, it is widely agreed that additional loci must contribute to psoriasis susceptibility, either by interacting directly with or by modifying the effect of the PSORS1 gene(s). To date, at least eight putative disease susceptibility regions have been mapped outside of the MHC (PSORS2-9). However, the search for the underlying genetic determinants has been seriously hindered by the difficulty of replicating linkage to these loci. The small disease-risk conferred by non-MHC genes and the likely occurrence of genetic heterogeneity are regarded as the main factors affecting the power of linkage studies and confounding the interpretation of experimental results. Evidence supporting some non-MHC loci has been provided by their close overlap with genomic regions conferring susceptibility to other inflammatory disorders. These observations indicate that clinically distinct autoimmune diseases might share common pathogenic pathways, suggesting that future advances in the understanding of single disorders could benefit the wider research community studying common inflammatory diseases.
Keywords: psoriasis susceptibility, non-mhc loci
Current Genomics
Title: The Long and Winding Road: Searching for Non-MHC Psoriasis Susceptibility Loci
Volume: 6 Issue: 1
Author(s): Francesca Capon and Emiliano Giardina
Affiliation:
Keywords: psoriasis susceptibility, non-mhc loci
Abstract: It is well recognised that the Major Histocompatibility Complex (MHC) harbours the main psoriasis susceptibility locus (PSORS1, Psoriasis Susceptibility 1). Nonetheless, linkage analyses have repeatedly shown that the PSORS1 locus account for less than 50% of the disease family clustering. On this basis, it is widely agreed that additional loci must contribute to psoriasis susceptibility, either by interacting directly with or by modifying the effect of the PSORS1 gene(s). To date, at least eight putative disease susceptibility regions have been mapped outside of the MHC (PSORS2-9). However, the search for the underlying genetic determinants has been seriously hindered by the difficulty of replicating linkage to these loci. The small disease-risk conferred by non-MHC genes and the likely occurrence of genetic heterogeneity are regarded as the main factors affecting the power of linkage studies and confounding the interpretation of experimental results. Evidence supporting some non-MHC loci has been provided by their close overlap with genomic regions conferring susceptibility to other inflammatory disorders. These observations indicate that clinically distinct autoimmune diseases might share common pathogenic pathways, suggesting that future advances in the understanding of single disorders could benefit the wider research community studying common inflammatory diseases.
Export Options
About this article
Cite this article as:
Capon Francesca and Giardina Emiliano, The Long and Winding Road: Searching for Non-MHC Psoriasis Susceptibility Loci, Current Genomics 2005; 6 (1) . https://dx.doi.org/10.2174/1389202053202102
DOI https://dx.doi.org/10.2174/1389202053202102 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Immuno - Functionalized Silver Nanoparticles for Diagnostics, Therapeutics and Protection of Rabies Viral Infection
Current Nanomedicine From Cannabis to Endocannabinoids in Multiple Sclerosis: A Paradigm of Central Nervous System Autoimmune Diseases
Current Drug Targets - CNS & Neurological Disorders Gene Therapy Strategies Towards Immune Tolerance to Treat the Autoimmune Diseases
Current Gene Therapy Vitamin D Receptor as a Drug Discovery Target
Mini-Reviews in Medicinal Chemistry Further Vitamin D Analogs
Current Vascular Pharmacology Regulation of the Immune Response by Natural IgM: Lessons from Warm Autoimmune Hemolytic Anemia
Current Pharmaceutical Design An Update on Autoinflammatory Diseases
Current Medicinal Chemistry Targeting Regulatory T Cells in the Treatment of Type 1 Diabetes Mellitus
Current Molecular Medicine Thalidomide as an Immunotherapeutic Agent: The Effects on Neutrophil- Mediated Inflammation
Current Pharmaceutical Design Roles of Glycans and Glycopeptides in Immune System and Immune-Related Diseases
Current Medicinal Chemistry Signaling Pathways Associated with Inflammatory Bowel Disease
Recent Patents on Inflammation & Allergy Drug Discovery Autoimmunity and Frontotemporal Dementia
Current Alzheimer Research Vitamin D : Autoimmunity and Gender
Current Medicinal Chemistry Kynurenine System and Multiple Sclerosis, Pathomechanism and Drug Targets with An Emphasis on Laquinimod
Current Drug Targets Mucosal Healing in Ulcerative Colitis: Where do we Stand?
Current Drug Targets Immune Aging and Autoimmune Diseases in Children
Current Immunology Reviews (Discontinued) Involvement of Membrane Channels in Autoimmune Disorders
Current Pharmaceutical Design Therapeutic Targeting of CD6 in Autoimmune Diseases: A Review of Cuban Clinical Studies with the Antibodies IOR-T1 and Itolizumab
Current Drug Targets Tolerance in the Absence of Autoantigen
Endocrine, Metabolic & Immune Disorders - Drug Targets Celastrol and Terpenes as Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry