Abstract
This review presents a link between histamine and epilepsy and provides the experimental evidence available so far on the effect of histamine and histaminergic agents in various seizure models. Agents that deplete brain histamine potentiate experimental convulsions while those enhancing tend to have anticonvulsant effects. Such effects are shown to be mediated via H1 and / or H3 but not H2 receptors. Lately, a large number of selective ligands for H3-receptors have been developed. Antagonists of these receptors have shown encouraging anticonvulsant effects in animal models and hold promise for potential therapeutic applications.
Keywords: brain histamine, epilepsy, seizures, convulsions, antagonists
Current Neuropharmacology
Title: Histamine as an Anticonvulsant Inhibitory Neurotransmitter
Volume: 2 Issue: 4
Author(s): Divya Vohora, S. N. Pal and K. K. Pillai
Affiliation:
Keywords: brain histamine, epilepsy, seizures, convulsions, antagonists
Abstract: This review presents a link between histamine and epilepsy and provides the experimental evidence available so far on the effect of histamine and histaminergic agents in various seizure models. Agents that deplete brain histamine potentiate experimental convulsions while those enhancing tend to have anticonvulsant effects. Such effects are shown to be mediated via H1 and / or H3 but not H2 receptors. Lately, a large number of selective ligands for H3-receptors have been developed. Antagonists of these receptors have shown encouraging anticonvulsant effects in animal models and hold promise for potential therapeutic applications.
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Cite this article as:
Vohora Divya, Pal N. S. and Pillai K. K., Histamine as an Anticonvulsant Inhibitory Neurotransmitter, Current Neuropharmacology 2004; 2 (4) . https://dx.doi.org/10.2174/1570159043359459
DOI https://dx.doi.org/10.2174/1570159043359459 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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