Abstract
Cancers can adapt several evasive functions including apoptosis evasion, self-sufficiency in growth signals, insensitivity to anti-growth signals, sustained angiogenesis, limitless replication potential, tissue invasion and metastasis. The invariable hurdle for development of therapies against such aberrant conditions requires both selective and potent cytotoxicity. Analysis of HIV-1 Vprs apoptotic and anti-proliferative activity have revealed potentially important implications for cancer therapy. Accordingly, we have reviewed the properties of Vpr that will likely contribute to its efficacious function as an anti-tumor agent. Among these are its ability to induce cell cycle arrest, inhibit inflammation, provoke p53 independent apoptosis, and selective killing of rapidly dividing cells.
Keywords: hiv-1, vpr, nf-kappab, p53, mitochondria, cancer, caspase and apoptosis
Current Drug Delivery
Title: HIV-1 Vpr: Enhancing Sensitivity of Tumors to Apoptosis
Volume: 1 Issue: 4
Author(s): Karuppiah Muthumani, Andrew Y. Choo, Daniel S. Hwang, Kenneth E. Ugen and David B. Weiner
Affiliation:
Keywords: hiv-1, vpr, nf-kappab, p53, mitochondria, cancer, caspase and apoptosis
Abstract: Cancers can adapt several evasive functions including apoptosis evasion, self-sufficiency in growth signals, insensitivity to anti-growth signals, sustained angiogenesis, limitless replication potential, tissue invasion and metastasis. The invariable hurdle for development of therapies against such aberrant conditions requires both selective and potent cytotoxicity. Analysis of HIV-1 Vprs apoptotic and anti-proliferative activity have revealed potentially important implications for cancer therapy. Accordingly, we have reviewed the properties of Vpr that will likely contribute to its efficacious function as an anti-tumor agent. Among these are its ability to induce cell cycle arrest, inhibit inflammation, provoke p53 independent apoptosis, and selective killing of rapidly dividing cells.
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Cite this article as:
Muthumani Karuppiah, Choo Y. Andrew, Hwang S. Daniel, Ugen E. Kenneth and Weiner B. David, HIV-1 Vpr: Enhancing Sensitivity of Tumors to Apoptosis, Current Drug Delivery 2004; 1 (4) . https://dx.doi.org/10.2174/1567201043334614
DOI https://dx.doi.org/10.2174/1567201043334614 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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