Abstract
Stroke,is the third leading cause of death and disability in the Western world.Stroke refers to set of ischemic conditions resulting from the occlusion or hemorrhage of blood vessels supplying the brain.Loss of blood flow to the brain results in neuronal injury due to both oxygen and nutrient deprivation and the activation of injurious signal cascades.Ultimately cerebral ischemia results in death and dysfunction of brain cells,and neurological deficits that reflect the location and size of the compromised brain area.Injury due to ischemic stroke occurs by a highly choreographed series of complex spatial and temporal events that evolve over hours to days.These events involve complex interactions between fundamental cell injury mechanisms including excitotoxicity and ionic imbalance, oxidative and nitrosative stress,apoptotic-like cell death and inflammatory responses.Genetically engineered mice have been valuable tools to probe putative mechanisms of neuronal death and uncover potential strategies that might render neurons resistant to ischemic injury.Findings from experimental stroke studies in genetically engineered animals are discussed.
Keywords: Ischemic Injury, apoptotic, hemorrhage, nitrosative
Current Molecular Medicine
Title: What have Genetically Engineered Mice Taught Us About Ischemic Injury?
Volume: 4 Issue: 2
Author(s): Dong Liang, Ted M. Dawson and Valina L. Dawson
Affiliation:
Keywords: Ischemic Injury, apoptotic, hemorrhage, nitrosative
Abstract: Stroke,is the third leading cause of death and disability in the Western world.Stroke refers to set of ischemic conditions resulting from the occlusion or hemorrhage of blood vessels supplying the brain.Loss of blood flow to the brain results in neuronal injury due to both oxygen and nutrient deprivation and the activation of injurious signal cascades.Ultimately cerebral ischemia results in death and dysfunction of brain cells,and neurological deficits that reflect the location and size of the compromised brain area.Injury due to ischemic stroke occurs by a highly choreographed series of complex spatial and temporal events that evolve over hours to days.These events involve complex interactions between fundamental cell injury mechanisms including excitotoxicity and ionic imbalance, oxidative and nitrosative stress,apoptotic-like cell death and inflammatory responses.Genetically engineered mice have been valuable tools to probe putative mechanisms of neuronal death and uncover potential strategies that might render neurons resistant to ischemic injury.Findings from experimental stroke studies in genetically engineered animals are discussed.
Export Options
About this article
Cite this article as:
Liang Dong, Dawson M. Ted and Dawson L. Valina, What have Genetically Engineered Mice Taught Us About Ischemic Injury?, Current Molecular Medicine 2004; 4 (2) . https://dx.doi.org/10.2174/1566524043479194
DOI https://dx.doi.org/10.2174/1566524043479194 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Novel Monoclonal Antibodies for the Treatment of Chronic Lymphocytic Leukemia
Current Cancer Drug Targets Current Management and Treatment of Cerebral Vasospasm Complicating SAH
CNS & Neurological Disorders - Drug Targets Editorial [Hot Topic:Applications of Angiotensin Converting Enzyme Inhibitors and of Angiotensin II Receptor Blockers in Pharmacology and Therapy: An Update (Executive Editor: Agostino Molteni)]
Current Pharmaceutical Design An Update on Drug Interactions with the Herbal Medicine Ginkgo biloba
Current Drug Metabolism The Role of Chymase in Vascular Remodeling and Tissue Fibrosis
Current Hypertension Reviews Recent Advances in the Treatment of Neurogenic Erectile Dysfunction
Recent Patents on CNS Drug Discovery (Discontinued) Artemisia Species as a New Candidate for Diabetes Therapy: A Comprehensive Review
Current Molecular Medicine The Validity of Chemical Analytical Methods by the Example of the Heparin Product Recall
Current Pharmaceutical Analysis Relaxin as a Cardiovascular Drug: A Promise Kept
Current Drug Safety Effect of Antipsychotic Drugs on Cerebrovascular Morbidity and Mortality: A Systematic Review
Current Drug Therapy Tubulin Colchicine Binding Site Inhibitors as Vascular Disrupting Agents in Clinical Developments
Current Medicinal Chemistry Alpha-2 Adrenoceptor Ligands and Opioid Drugs: Pharmacological Interactions of Therapeutic Interest
Current Neuropharmacology Spontaneous Coronary Artery Dissection: Does Being Unemployed Matter? Insights from the GSCAD Registry
Current Cardiology Reviews Fatal Disseminated Toxoplasmosis During Primary HIV Infection
Current HIV Research Subject Index to Volume 9
Current Pharmaceutical Design Muscarinic Receptors as Targets for Metronomic Therapy in Breast Cancer
Current Pharmaceutical Design Ruthenium as an Effective Nitric Oxide Scavenger
Current Topics in Medicinal Chemistry From Anti-allergic to Anti-Alzheimer ’ s: Molecular Pharmacology of Dimebon™
Current Alzheimer Research Engineered Inorganic/Organic-Core/Shell Magnetic Fe<sub>x</sub>O<sub>y</sub> Nanoparticles with Oleic Acid and/or Oleylamine As Capping Agents
Current Pharmaceutical Design Immunossupressant and Organ Transplantation: Immunophilins Targeting Agent and Alternative Therapies
Current Medicinal Chemistry