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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Combinatorial Protein Biochemistry for Therapeutics and Proteomics

Author(s): David Lowe and Lutz Jermutus

Volume 5, Issue 1, 2004

Page: [17 - 27] Pages: 11

DOI: 10.2174/1389201043489585

Price: $65

Abstract

This paper reviews progress towards the customised generation of proteins for applications as therapeutics, diagnostics and in proteomics. It particularly focuses on combinatorial approaches where proteins with pre-defined biochemical and biophysical characteristics are selected from large variant libraries.

Keywords: protein therapeutic, protein engineering, display, directed evolution, alternative frameworks


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