Abstract
The name “Cannabinoid” applies to a large and diverse family of compounds including plant derived, synthetic and endogenously produced chemicals, some but not all of which are psychotropic. Cannabinoids of all classes have the ability to protect neurons from a variety of insults that are believed to underlie delayed neuronal death after traumatic brain injury (TBI), including excitotoxicity, calcium influx, free radical formation and neuroinflammation. The pathways and experimental models supporting a neuroprotective role for the various classes of cannabinoids are critically reviewed vis a vis their potential to support the development of a clinically viable neuroprotective agent for human TBI.
Keywords: head injury, cannabimimetics, marihuana products, endocannabinoids, cannabinoid receptors, antioxidants
Current Pharmaceutical Design
Title: Cannabinoids as Neuroprotective Agents in Traumatic Brain Injury
Volume: 10 Issue: 18
Author(s): Anat Biegon
Affiliation:
Keywords: head injury, cannabimimetics, marihuana products, endocannabinoids, cannabinoid receptors, antioxidants
Abstract: The name “Cannabinoid” applies to a large and diverse family of compounds including plant derived, synthetic and endogenously produced chemicals, some but not all of which are psychotropic. Cannabinoids of all classes have the ability to protect neurons from a variety of insults that are believed to underlie delayed neuronal death after traumatic brain injury (TBI), including excitotoxicity, calcium influx, free radical formation and neuroinflammation. The pathways and experimental models supporting a neuroprotective role for the various classes of cannabinoids are critically reviewed vis a vis their potential to support the development of a clinically viable neuroprotective agent for human TBI.
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Cite this article as:
Biegon Anat, Cannabinoids as Neuroprotective Agents in Traumatic Brain Injury, Current Pharmaceutical Design 2004; 10 (18) . https://dx.doi.org/10.2174/1381612043384196
DOI https://dx.doi.org/10.2174/1381612043384196 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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