Abstract
Corticotropin-releasing factor (CRF) and its related peptides play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two G-protein-coupled receptors encoded by separate genes, termed CRF-R1 and -R2. In this review we focus on the structure, phylogeny, and expression of CRF peptide family. We present up-to-date literature on divergent actions of the CRF peptide family, including stress and behaviour, cardiovascular physiology, energy balance and re pr oduction. We also pr ese nt a br ief over view of CRF rec eptor s inc luding pha rmacologic al aspe cts a nd potential therapeutic interventions for CRF receptors.
Keywords: corticotropin releasing factor, stressful stimuli, protein-coupled receptors, crf peptide family
Current Genomics
Title: Corticotropin Releasing Factor (CRF) Peptide Family and their Receptors: Divergent Actions Influencing Human Physiology
Volume: 5 Issue: 6
Author(s): E. Karteris, H. S. Randeva and E. W. Hillhouse
Affiliation:
Keywords: corticotropin releasing factor, stressful stimuli, protein-coupled receptors, crf peptide family
Abstract: Corticotropin-releasing factor (CRF) and its related peptides play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two G-protein-coupled receptors encoded by separate genes, termed CRF-R1 and -R2. In this review we focus on the structure, phylogeny, and expression of CRF peptide family. We present up-to-date literature on divergent actions of the CRF peptide family, including stress and behaviour, cardiovascular physiology, energy balance and re pr oduction. We also pr ese nt a br ief over view of CRF rec eptor s inc luding pha rmacologic al aspe cts a nd potential therapeutic interventions for CRF receptors.
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Cite this article as:
Karteris E., Randeva S. H. and Hillhouse W. E., Corticotropin Releasing Factor (CRF) Peptide Family and their Receptors: Divergent Actions Influencing Human Physiology, Current Genomics 2004; 5 (6) . https://dx.doi.org/10.2174/1389202043348968
DOI https://dx.doi.org/10.2174/1389202043348968 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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