Abstract
Acyclic nucleoside phosphonates (ANP) are analogs of nucleotides exhibiting various biological (e.g. antiviral, cytostatic, antiparasitic, immunomodulatory) activities. This review describes synthetic approaches to their preparation, biological activities, structure-activity relationships and mode of action of ANPs, with emphasis to selected drugs or drug candidates. Three compounds of the ANP group (cidofovir, adefovir, tenofovir) are active components of potent antivirals approved for therapeutic use in human medicine aimed at hepatitis B, AIDS and various diseases caused by DNA viruses.
Keywords: adefovir, cidofovir, tenofovir, aids, hepatitis b, dna viruses, retroviruses
Current Pharmaceutical Design
Title: Phosphonomethoxyalkyl Analogs of Nucleotides
Volume: 9 Issue: 31
Author(s): Antonin Holy
Affiliation:
Keywords: adefovir, cidofovir, tenofovir, aids, hepatitis b, dna viruses, retroviruses
Abstract: Acyclic nucleoside phosphonates (ANP) are analogs of nucleotides exhibiting various biological (e.g. antiviral, cytostatic, antiparasitic, immunomodulatory) activities. This review describes synthetic approaches to their preparation, biological activities, structure-activity relationships and mode of action of ANPs, with emphasis to selected drugs or drug candidates. Three compounds of the ANP group (cidofovir, adefovir, tenofovir) are active components of potent antivirals approved for therapeutic use in human medicine aimed at hepatitis B, AIDS and various diseases caused by DNA viruses.
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Cite this article as:
Holy Antonin, Phosphonomethoxyalkyl Analogs of Nucleotides, Current Pharmaceutical Design 2003; 9 (31) . https://dx.doi.org/10.2174/1381612033453668
DOI https://dx.doi.org/10.2174/1381612033453668 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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