Abstract
Solid phase synthesis has become a routine technique in combinatorial chemistry. The need in analytical methods to characterize nondestructively resin bound molecules has been fulfilled by the introduction of High Resolution Magic Angle Spinning (HR MAS) NMR of solvent swollen beads. HR MAS NMR can give solution like proton NMR spectra and one- and two-dimensional NMR techniques are amenable, allowing detailed structure analysis. Recent developments are the application of a diffusion filter to suppress solvent signals and dipolar recoupling techniques to gain spatial information. HR MAS NMR has been applied to monitor reactions and elucidate reaction products.
Keywords: high resolution magic angle spinning nmr, hr mas nmr, diffusion filter, dipolar recoupling, combinatorial chemistry, reaction monitoring on bead
Combinatorial Chemistry & High Throughput Screening
Title: High Resolution Magic Angle Spinning NMR for Analyzing Small Molecules Attached to Solid Support
Volume: 6 Issue: 7
Author(s): Harald Schroder
Affiliation:
Keywords: high resolution magic angle spinning nmr, hr mas nmr, diffusion filter, dipolar recoupling, combinatorial chemistry, reaction monitoring on bead
Abstract: Solid phase synthesis has become a routine technique in combinatorial chemistry. The need in analytical methods to characterize nondestructively resin bound molecules has been fulfilled by the introduction of High Resolution Magic Angle Spinning (HR MAS) NMR of solvent swollen beads. HR MAS NMR can give solution like proton NMR spectra and one- and two-dimensional NMR techniques are amenable, allowing detailed structure analysis. Recent developments are the application of a diffusion filter to suppress solvent signals and dipolar recoupling techniques to gain spatial information. HR MAS NMR has been applied to monitor reactions and elucidate reaction products.
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Cite this article as:
Schroder Harald, High Resolution Magic Angle Spinning NMR for Analyzing Small Molecules Attached to Solid Support, Combinatorial Chemistry & High Throughput Screening 2003; 6 (7) . https://dx.doi.org/10.2174/138620703771981269
DOI https://dx.doi.org/10.2174/138620703771981269 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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