Abstract
Considerable effort has led to an increased interest in emerging preclinical and clinical data regarding the pathophysiological changes in the posttraumatic brain. It is widely believed that delayed cell damage and death contributes to behavioral impairment following traumatic brain injury. However, no drug therapy to attenuate this process is available at present, and the development of new therapeutic regimen is urgently warranted. This manuscript represents a compendium of recent preclinical work undertaken to evaluate new pharmacologic strategies in the experimental setting as a first step towards the development of a therapeutic armamentarium directed to improve functional recovery in head-injured patients.
Keywords: Pharmacology therapy, Traumatic brain injury, Cation homeostasis, Glutamate antagonists, Calpain antagonists, Cytoskeleton, Nitric oxide, Nitric oxide synthetase, Free rasical scavengers, Lipid peroxidation
Current Pharmaceutical Design
Title: Pharmacologic Therapy In Traumatic Brain Injury: Update On Experimental Treatment Strategies
Volume: 7 Issue: 15
Author(s): H. L. Laurer and T. K. McIntosh
Affiliation:
Keywords: Pharmacology therapy, Traumatic brain injury, Cation homeostasis, Glutamate antagonists, Calpain antagonists, Cytoskeleton, Nitric oxide, Nitric oxide synthetase, Free rasical scavengers, Lipid peroxidation
Abstract: Considerable effort has led to an increased interest in emerging preclinical and clinical data regarding the pathophysiological changes in the posttraumatic brain. It is widely believed that delayed cell damage and death contributes to behavioral impairment following traumatic brain injury. However, no drug therapy to attenuate this process is available at present, and the development of new therapeutic regimen is urgently warranted. This manuscript represents a compendium of recent preclinical work undertaken to evaluate new pharmacologic strategies in the experimental setting as a first step towards the development of a therapeutic armamentarium directed to improve functional recovery in head-injured patients.
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Cite this article as:
Laurer L. H. and McIntosh K. T., Pharmacologic Therapy In Traumatic Brain Injury: Update On Experimental Treatment Strategies, Current Pharmaceutical Design 2001; 7 (15) . https://dx.doi.org/10.2174/1381612013397285
DOI https://dx.doi.org/10.2174/1381612013397285 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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