Abstract
Drug delivery systems largely contribute to cancer therapy in terms of tumor targeting and controlled release of cargo molecules. While targeting of tumor “tissue” has been achieved using nanocarriers, delivery of cargo molecules into tumor cells is still challenging. Intracellular delivery of nanocarriers is an essential process to overcome multi-drug resistance and for the delivery of cargo molecules for both therapy and vaccine applications. Nanocarriers may gain access to the interior of target cells either non-specifically, as in adsorptive endocytosis, or specifically, as in receptor-mediated endocytosis. Once internalized, they must subsequently break free of their endosomal compartments in order to deliver their cargo into either the cytosol or nucleus. If the nucleus is the target, as in DNA delivery, the nanocarrier must then traffick to the perinuclear region and deliver the cargo into the nucleus, either by physically transporting DNA through the nuclear pore complex (NPC), or by releasing DNA at the door of the NPC, allowing free DNA to gain access. This review article includes both principles and mechanisms of intracellular delivery of nanocarriers, and gives a few examples of their application.
Keywords: Intracellular delivery, cancer therapy, liposomes, polymeric carriers, nanoparticles, mechanisms
Current Nanoscience
Title: Intracellular Delivery of Nanocarriers for Cancer Therapy
Volume: 3 Issue: 4
Author(s): Yah-el Har-el and Yoshinori Kato
Affiliation:
Keywords: Intracellular delivery, cancer therapy, liposomes, polymeric carriers, nanoparticles, mechanisms
Abstract: Drug delivery systems largely contribute to cancer therapy in terms of tumor targeting and controlled release of cargo molecules. While targeting of tumor “tissue” has been achieved using nanocarriers, delivery of cargo molecules into tumor cells is still challenging. Intracellular delivery of nanocarriers is an essential process to overcome multi-drug resistance and for the delivery of cargo molecules for both therapy and vaccine applications. Nanocarriers may gain access to the interior of target cells either non-specifically, as in adsorptive endocytosis, or specifically, as in receptor-mediated endocytosis. Once internalized, they must subsequently break free of their endosomal compartments in order to deliver their cargo into either the cytosol or nucleus. If the nucleus is the target, as in DNA delivery, the nanocarrier must then traffick to the perinuclear region and deliver the cargo into the nucleus, either by physically transporting DNA through the nuclear pore complex (NPC), or by releasing DNA at the door of the NPC, allowing free DNA to gain access. This review article includes both principles and mechanisms of intracellular delivery of nanocarriers, and gives a few examples of their application.
Export Options
About this article
Cite this article as:
Har-el Yah-el and Kato Yoshinori, Intracellular Delivery of Nanocarriers for Cancer Therapy, Current Nanoscience 2007; 3 (4) . https://dx.doi.org/10.2174/157341307782418612
DOI https://dx.doi.org/10.2174/157341307782418612 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Advances in Clinical Study of Curcumin
Current Pharmaceutical Design Repurposing Drugs for Skin Cancer
Current Medicinal Chemistry Intracellular and Extracellular miRNAs in Regulation of Angiogenesis Signaling
Current Angiogenesis (Discontinued) Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications
Current Drug Targets Engineering of Therapeutic Proteins Production in Escherichia coli
Current Pharmaceutical Biotechnology Emerging Anabolic Treatments in Osteoporosis
Current Drug Safety Chemoprevention of Colorectal Cancer: Progress or Pipedream?
Current Cancer Therapy Reviews Development of Small-Molecule Inhibitors of Raf
Recent Patents on Anti-Infective Drug Discovery Chemoprevention of Cancer by Isothiocyanates and Anthocyanins: Mechanisms of Action and Structure-Activity Relationship
Current Medicinal Chemistry Amino Acid Transporter-Targeted Radiotracers for Molecular Imaging in Oncology
Current Medicinal Chemistry α-Lipoic Acid Supplementation: A Tool for Obesity Therapy?
Current Pharmaceutical Design Assessment of Ploy Dopamine Coated Fe<sub>3</sub>O<sub>4</sub> Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection
Anti-Cancer Agents in Medicinal Chemistry Clinical Significance of Breast Cancer Resistance Protein/ABCG2 in the Management of Malignancy
Clinical Cancer Drugs Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis
Anti-Cancer Agents in Medicinal Chemistry Can Combined Therapy Benefit Immune Checkpoint Blockade Response in Hepatocellular Carcinoma?
Anti-Cancer Agents in Medicinal Chemistry The mTOR Signaling Network: Insights from Its Role During Embryonic Development
Current Medicinal Chemistry Prenylated Coumarins of the Genus Citrus: An Overview of the 2006- 2016 Literature Data
Current Medicinal Chemistry A Bioinorganic Perspective on Matrix Metalloproteinase Inhibition
Current Topics in Medicinal Chemistry Role of Lipid Rafts/Caveolae in the Anticancer Effect of Endocannabinoids
Mini-Reviews in Medicinal Chemistry Hyperprolactinemia Secondary to Pituitary Microadenoma Versus Haloperidol- A Diagnostic Enigma. A Case Report and Brief Review
Current Drug Safety