Abstract
A lot of experimental data has been produced which suggests that there is a crucial role for glycans during the different stages of melanoma progression. Malignant transformation is associated with various alterations in the glycosylation pattern of the protein glycans. The most common changes are associated with the presence of more branched and hypersialylated N-linked oligosaccharides, re-expression of fetal-type antigens and premature terminated glycans. Some of these changes may provide the tumor cells with an advantage in influencing their social behavior and facilitating metastasis formation so, glycan-target therapy in combination with existing protocols may have an important impact in the treatment of melanoma.
Keywords: Glycan markers, glycosyltransferases, melanoma, transformation
Current Cancer Therapy Reviews
Title: Protein Glycosylation as Marker of Melanoma Progression
Volume: 4 Issue: 2
Author(s): Anna Litynska, Malgorzata Przybylo, Dorota Hoja-Lukowicz, Ewa Pochec, Marcelina Kremser, Dorota Ciolczyk-Wierzbicka, Maria Labedz and Piotr Laidler
Affiliation:
Keywords: Glycan markers, glycosyltransferases, melanoma, transformation
Abstract: A lot of experimental data has been produced which suggests that there is a crucial role for glycans during the different stages of melanoma progression. Malignant transformation is associated with various alterations in the glycosylation pattern of the protein glycans. The most common changes are associated with the presence of more branched and hypersialylated N-linked oligosaccharides, re-expression of fetal-type antigens and premature terminated glycans. Some of these changes may provide the tumor cells with an advantage in influencing their social behavior and facilitating metastasis formation so, glycan-target therapy in combination with existing protocols may have an important impact in the treatment of melanoma.
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Litynska Anna, Przybylo Malgorzata, Hoja-Lukowicz Dorota, Pochec Ewa, Kremser Marcelina, Ciolczyk-Wierzbicka Dorota, Labedz Maria and Laidler Piotr, Protein Glycosylation as Marker of Melanoma Progression, Current Cancer Therapy Reviews 2008; 4 (2) . https://dx.doi.org/10.2174/157339408784310115
DOI https://dx.doi.org/10.2174/157339408784310115 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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