Abstract
Both stem cells and cancer cells can proliferate indefinitely. In many case, cancers consist of the cells expressing tissue-specific stem cell markers and the cells expressing differentiation markers. Moreover, it has been revealed that many cancer cells express ATP-binding cassette (ABC) transporters, by which the cells pump out a specific fluorescence dyes as well as anti-cancer drugs. Thus these finding suggest that either cancer cells resemble stem cells or cancers contain stem cell-like cells. Using the common characteristics between brain cancer cells and neural stem cells, several research groups have succeeded to identify stem cell-like brain cancer cells (called “brain cancer stem cells”) in brain tumors and brain cancer cell lines. The brain cancer stem cells, but not the other cancer cells, self-renew, form tumors when transplanted in vivo, and are highly resistant for both anti-cancer drugs and irradiation. Together all, these recent progresses suggest that it is crucial to characterize brain cancer stem cells and identify targets for the therapy.
Keywords: Cancer stem cells (CSCs), CD133, side population (SP), cell of origin, neural stem cells (NSCs)
Current Cancer Therapy Reviews
Title: Stem Cell-Like Brain Cancer Cells
Volume: 4 Issue: 3
Author(s): Toru Kondo
Affiliation:
Keywords: Cancer stem cells (CSCs), CD133, side population (SP), cell of origin, neural stem cells (NSCs)
Abstract: Both stem cells and cancer cells can proliferate indefinitely. In many case, cancers consist of the cells expressing tissue-specific stem cell markers and the cells expressing differentiation markers. Moreover, it has been revealed that many cancer cells express ATP-binding cassette (ABC) transporters, by which the cells pump out a specific fluorescence dyes as well as anti-cancer drugs. Thus these finding suggest that either cancer cells resemble stem cells or cancers contain stem cell-like cells. Using the common characteristics between brain cancer cells and neural stem cells, several research groups have succeeded to identify stem cell-like brain cancer cells (called “brain cancer stem cells”) in brain tumors and brain cancer cell lines. The brain cancer stem cells, but not the other cancer cells, self-renew, form tumors when transplanted in vivo, and are highly resistant for both anti-cancer drugs and irradiation. Together all, these recent progresses suggest that it is crucial to characterize brain cancer stem cells and identify targets for the therapy.
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Cite this article as:
Kondo Toru, Stem Cell-Like Brain Cancer Cells, Current Cancer Therapy Reviews 2008; 4 (3) . https://dx.doi.org/10.2174/157339408785294258
DOI https://dx.doi.org/10.2174/157339408785294258 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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