Abstract
When used at a high dose, many anticancer drugs produce undesirable side effects including hepatotoxicity. Transdermal delivery bypasses first-pass metabolism, allowing the use of a lower dose of drug while decreasing systemic toxicity. In this review, we summarize various advanced technologies for improving anticancer drug delivery via the skin. This technology is discussed in the context of three anticancer drugs, 5-fluorouracil (5-FU), methotrexate (MTX) and 5-aminolevulinic acid (5-ALA). The use of a erbium:YAG (Er:YAG) laser for transdermal delivery of anticancer drugs is specifically highlighted in this review.
Keywords: Toxicity, transdermal delivery, laser, anticancer drugs
Current Drug Metabolism
Title: Decreasing Systemic Toxicity Via Transdermal Delivery of Anticancer Drugs
Volume: 9 Issue: 7
Author(s): Jia-You Fang, Pei-Feng Liu and Chun-Ming Huang
Affiliation:
Keywords: Toxicity, transdermal delivery, laser, anticancer drugs
Abstract: When used at a high dose, many anticancer drugs produce undesirable side effects including hepatotoxicity. Transdermal delivery bypasses first-pass metabolism, allowing the use of a lower dose of drug while decreasing systemic toxicity. In this review, we summarize various advanced technologies for improving anticancer drug delivery via the skin. This technology is discussed in the context of three anticancer drugs, 5-fluorouracil (5-FU), methotrexate (MTX) and 5-aminolevulinic acid (5-ALA). The use of a erbium:YAG (Er:YAG) laser for transdermal delivery of anticancer drugs is specifically highlighted in this review.
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Cite this article as:
Fang Jia-You, Liu Pei-Feng and Huang Chun-Ming, Decreasing Systemic Toxicity Via Transdermal Delivery of Anticancer Drugs, Current Drug Metabolism 2008; 9 (7) . https://dx.doi.org/10.2174/138920008785821693
DOI https://dx.doi.org/10.2174/138920008785821693 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
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