Abstract
The Oxazolidinones are a promising novel chemical synthetic class of antibiotics identified in the last two decades and have been subjected to intensive discovery efforts. They possess impressive antibacterial activity against Grampositive pathogens. Oxazolidinones act through a unique mechanism of inhibitory bacterial protein biosynthesis. Linezolid (ZyvoxTM) has been the only drug of oxazolidinone class to reach the market after USFDA approval. Here we review our efforts directed to the discovery of novel oxazolidinone antibacterials evolved through structure-activity relationship (SAR) and an overview of contemporary on going efforts.
Keywords: Oxazolidinones, Antibacterials, antibiotics, structure-activity relationship (SAR), antibacterial activity, synthetic compound
Anti-Infective Agents in Medicinal Chemistry
Title: Oxazolidinone Antibacterials and Our Experience
Volume: 7 Issue: 4
Author(s): Brijesh Kumar Srivastava, Rina Soni, Jayendra Z. Patel, Mukul R. Jain and Pankaj R. Patel
Affiliation:
Keywords: Oxazolidinones, Antibacterials, antibiotics, structure-activity relationship (SAR), antibacterial activity, synthetic compound
Abstract: The Oxazolidinones are a promising novel chemical synthetic class of antibiotics identified in the last two decades and have been subjected to intensive discovery efforts. They possess impressive antibacterial activity against Grampositive pathogens. Oxazolidinones act through a unique mechanism of inhibitory bacterial protein biosynthesis. Linezolid (ZyvoxTM) has been the only drug of oxazolidinone class to reach the market after USFDA approval. Here we review our efforts directed to the discovery of novel oxazolidinone antibacterials evolved through structure-activity relationship (SAR) and an overview of contemporary on going efforts.
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Cite this article as:
Srivastava Kumar Brijesh, Soni Rina, Patel Z. Jayendra, Jain R. Mukul and Patel R. Pankaj, Oxazolidinone Antibacterials and Our Experience, Anti-Infective Agents in Medicinal Chemistry 2008; 7 (4) . https://dx.doi.org/10.2174/187152108785908820
DOI https://dx.doi.org/10.2174/187152108785908820 |
Print ISSN 1871-5214 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6018 |
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