Abstract
Diabetes mellitus (DM) is not one disease but is a heterogonous group of syndromes. Contrary to the popular belief DM is a metabolic disorder characterized by increased blood glucose level (hyperglycemia) and this is because of insufficient or inefficient insulin secretary response. Glucose is the main energy source for the body, and in the case of DM, management of glucose becomes irregular. There are around 410 experimentally proven medicinal plants having antidiabetic properties but the complete mechanism of action is available only for about 109. There are several medicinal plants whose extract modulate glycolysis, Krebs cycle, gluconeogenesis, HMP shunt pathway, glycogen synthesis and their degradation, cholesterol synthesis, metabolism and absorption of carbohydrates, and synthesis and release of insulin. This paper provides a comprehensive review of the mode of action of medicinal plants that exhibit anti-diabetic properties.
Keywords: Diabetes mellitus, Hyperglycemia, Ayurveda, Anti-diabetic, Insulin
Current Diabetes Reviews
Title: A Target Based Therapeutic Approach Towards Diabetes Mellitus Using Medicinal Plants
Volume: 4 Issue: 4
Author(s): Pranav K. Prabhakar and Mukesh Doble
Affiliation:
Keywords: Diabetes mellitus, Hyperglycemia, Ayurveda, Anti-diabetic, Insulin
Abstract: Diabetes mellitus (DM) is not one disease but is a heterogonous group of syndromes. Contrary to the popular belief DM is a metabolic disorder characterized by increased blood glucose level (hyperglycemia) and this is because of insufficient or inefficient insulin secretary response. Glucose is the main energy source for the body, and in the case of DM, management of glucose becomes irregular. There are around 410 experimentally proven medicinal plants having antidiabetic properties but the complete mechanism of action is available only for about 109. There are several medicinal plants whose extract modulate glycolysis, Krebs cycle, gluconeogenesis, HMP shunt pathway, glycogen synthesis and their degradation, cholesterol synthesis, metabolism and absorption of carbohydrates, and synthesis and release of insulin. This paper provides a comprehensive review of the mode of action of medicinal plants that exhibit anti-diabetic properties.
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Cite this article as:
Prabhakar K. Pranav and Doble Mukesh, A Target Based Therapeutic Approach Towards Diabetes Mellitus Using Medicinal Plants, Current Diabetes Reviews 2008; 4 (4) . https://dx.doi.org/10.2174/157339908786241124
DOI https://dx.doi.org/10.2174/157339908786241124 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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