Abstract
The role of parent-of-origin effects (POE) in the etiology of complex diseases such as type 2 diabetes (T2DM) and obesity is currently of intense interest, but still largely unclear. POE are transmittable genetic effects whereby the expression of the phenotype in the offspring depends upon whether the transmission originated from the mother or father. In mammals, POE can be caused by genetic imprinting, intrauterine effects, or maternally inherited mitochondrial genes. In this paper, we describe the different mechanisms underlying POE, characterize known examples of POE in rare forms of diabetes, and review the evidence from linkage and association studies for POE in T2DM and obesity. Finally, we summarize some of the new and established statistical and experimental approaches commonly used to detect POE. Through this paper, we hope emphasizes the potentially significant importance of POE in the etiology of T2DM and obesity.
Keywords: Parent-of-origin effects, Imprinting, Mitochondrial genome, Intrauterine environment, Epigenetics, Type 2 diabetes, Obesity
Current Diabetes Reviews
Title: Investigating Parent of Origin Effects in Studies of Type 2 Diabetes and Obesity
Volume: 4 Issue: 4
Author(s): Evadnie Rampersaud, Braxton D. Mitchell, Adam C. Naj and Toni I. Pollin
Affiliation:
Keywords: Parent-of-origin effects, Imprinting, Mitochondrial genome, Intrauterine environment, Epigenetics, Type 2 diabetes, Obesity
Abstract: The role of parent-of-origin effects (POE) in the etiology of complex diseases such as type 2 diabetes (T2DM) and obesity is currently of intense interest, but still largely unclear. POE are transmittable genetic effects whereby the expression of the phenotype in the offspring depends upon whether the transmission originated from the mother or father. In mammals, POE can be caused by genetic imprinting, intrauterine effects, or maternally inherited mitochondrial genes. In this paper, we describe the different mechanisms underlying POE, characterize known examples of POE in rare forms of diabetes, and review the evidence from linkage and association studies for POE in T2DM and obesity. Finally, we summarize some of the new and established statistical and experimental approaches commonly used to detect POE. Through this paper, we hope emphasizes the potentially significant importance of POE in the etiology of T2DM and obesity.
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Cite this article as:
Rampersaud Evadnie, Mitchell D. Braxton, Naj C. Adam and Pollin I. Toni, Investigating Parent of Origin Effects in Studies of Type 2 Diabetes and Obesity, Current Diabetes Reviews 2008; 4 (4) . https://dx.doi.org/10.2174/157339908786241179
DOI https://dx.doi.org/10.2174/157339908786241179 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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