Abstract
A layered compound of zinc-aluminium layered double hydroxide (LDH) to be used as a host for a guest amino acid, glutamate was synthesized. Different parameters were used and optimized to form amino acid-intercalated pure phase materials. The resulting Bio-Inorganic Nanohybrid (BINH) was chosen for further characterization. BINH exhibits the glutamate to be in vertical or perpendicular orientation to the inorganic layer. Cytotoxicty test indicates that the IC50 value was observed at 3.125 μg/ml. Results from this study will be used in the development of a new delivery system for therapeutic agents comprising amino acids or peptides.
Keywords: Nanobiotechnology, glutamate, layered double hydroxide, bio-inorganic nanohybrid
Current Nanoscience
Title: Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study
Volume: 4 Issue: 4
Author(s): Mohd Mokrish Md Ajat, Khatijah Yusoff and Mohd Zobir Hussein
Affiliation:
Keywords: Nanobiotechnology, glutamate, layered double hydroxide, bio-inorganic nanohybrid
Abstract: A layered compound of zinc-aluminium layered double hydroxide (LDH) to be used as a host for a guest amino acid, glutamate was synthesized. Different parameters were used and optimized to form amino acid-intercalated pure phase materials. The resulting Bio-Inorganic Nanohybrid (BINH) was chosen for further characterization. BINH exhibits the glutamate to be in vertical or perpendicular orientation to the inorganic layer. Cytotoxicty test indicates that the IC50 value was observed at 3.125 μg/ml. Results from this study will be used in the development of a new delivery system for therapeutic agents comprising amino acids or peptides.
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Md Ajat Mokrish Mohd, Yusoff Khatijah and Hussein Zobir Mohd, Synthesis of Glutamate-Zinc-Aluminium-Layered Double Hydroxide Nanobiocomposites and Cell Viability Study, Current Nanoscience 2008; 4 (4) . https://dx.doi.org/10.2174/157341308786306161
DOI https://dx.doi.org/10.2174/157341308786306161 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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