Abstract
There is considerable interest in the therapeutic utility of inhibiting cellular trafficking in a variety of inflammatory diseases. Approaches including inhibition of adhesion molecule function and in particular of chemokine effector function have met with high levels of success in many models of disease but have been of less value in application to clinical disease states. Although this may in part be explained by pharmacokinetic and pharmacodynamic issues surrounding therapeutic agents tried thus far, it is also likely that functional redundancy in the chemokine network may pose significant problems for achieving potent inflammation suppression. The atypical chemokine receptors comprise a novel group of receptors capable of binding to several chemokine activities and to inhibiting their function. This review will describe the basic biology of such receptors and speculate on their potential as therapeutic agents moving forward.
Keywords: Chemokine, cytokine, inflammation, autoimmunity, pathogenesis, psoriasis
Current Molecular Medicine
Title: Atypical Chemokine Receptors in Inflammatory Disease
Volume: 9 Issue: 1
Author(s): Manish Patel, Iain B. McInnes and Gerard Graham
Affiliation:
Keywords: Chemokine, cytokine, inflammation, autoimmunity, pathogenesis, psoriasis
Abstract: There is considerable interest in the therapeutic utility of inhibiting cellular trafficking in a variety of inflammatory diseases. Approaches including inhibition of adhesion molecule function and in particular of chemokine effector function have met with high levels of success in many models of disease but have been of less value in application to clinical disease states. Although this may in part be explained by pharmacokinetic and pharmacodynamic issues surrounding therapeutic agents tried thus far, it is also likely that functional redundancy in the chemokine network may pose significant problems for achieving potent inflammation suppression. The atypical chemokine receptors comprise a novel group of receptors capable of binding to several chemokine activities and to inhibiting their function. This review will describe the basic biology of such receptors and speculate on their potential as therapeutic agents moving forward.
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Cite this article as:
Patel Manish, McInnes B. Iain and Graham Gerard, Atypical Chemokine Receptors in Inflammatory Disease, Current Molecular Medicine 2009; 9 (1) . https://dx.doi.org/10.2174/156652409787314480
DOI https://dx.doi.org/10.2174/156652409787314480 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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