Abstract
Inflammation and autoimmune disorders have received much greater attention in the recent years due to the elucidation of various molecular mechanisms and the discoveries of various cytokines and other proteins involved in these processes. These discoveries are helping develop novel therapeutics including small molecules and protein therapeutics (biologics) for the treatment of sterile and nonsterile inflammatory disorders. Small molecule drugs have several advantages over protein therapeutics including their affordability for chronic treatments. In this review article, recent successes targeting various inflammatory cytokines and the corresponding receptors such as TLRs, interleukins, p38α as well as recent strategies for developing small molecule antagonists using rational models are discussed.
Keywords: Inflammation, Cytokines, Small molecule targets, Toll-like receptors, p38α kinase, Interferon, autoimmune disorders, pathogens, macrophages, fibrosis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Immunological Targets in Inflammation from the Small Molecule Perspective
Volume: 10 Issue: 2
Author(s): Angelica M. Bello, Meena K. Purohit, Tracy Jun Yang Cui, Slater Brandon Stead and Lakshmi P. Kotra
Affiliation:
Keywords: Inflammation, Cytokines, Small molecule targets, Toll-like receptors, p38α kinase, Interferon, autoimmune disorders, pathogens, macrophages, fibrosis
Abstract: Inflammation and autoimmune disorders have received much greater attention in the recent years due to the elucidation of various molecular mechanisms and the discoveries of various cytokines and other proteins involved in these processes. These discoveries are helping develop novel therapeutics including small molecules and protein therapeutics (biologics) for the treatment of sterile and nonsterile inflammatory disorders. Small molecule drugs have several advantages over protein therapeutics including their affordability for chronic treatments. In this review article, recent successes targeting various inflammatory cytokines and the corresponding receptors such as TLRs, interleukins, p38α as well as recent strategies for developing small molecule antagonists using rational models are discussed.
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Cite this article as:
M. Bello Angelica, K. Purohit Meena, Jun Yang Cui Tracy, Brandon Stead Slater and P. Kotra Lakshmi, Immunological Targets in Inflammation from the Small Molecule Perspective, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (2) . https://dx.doi.org/10.2174/1871523011107020121
DOI https://dx.doi.org/10.2174/1871523011107020121 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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