Abstract
Reperfusion therapy has significantly improved survival and prognosis of patients with acute myocardial infarction. However, the development of heart failure, particularly in patients after a large myocardial damage, remains a major challenge. Cell therapy may provide a novel therapeutic option to modify left ventricular remodeling processes and prevent postinfarction heart failure. Experimental studies have suggested that the infusion of different subsets of bone marrow-derived progenitor cells, circulating endothelial progenitor cells, or tissue-residing stem cells improved neovascularization and cardiac function. Clinical studies at present predominantly used bone marrow mononuclear cells (BMNC) isolated from bone marrow aspirates by density gradient centrifugation. Intracoronary infusion of BMNC significantly increased global or regional ejection fraction and/or reduced infarct size and endsystolic volumes in patients with acute myocardial infarction as demonstrated in initial pilot trials and in randomized studies. We aim to review the existing evidence of the beneficial effect of BMNC infusion as well the controversial issues regarding this promising novel therapeutic approach.
Keywords: Cardiac regeneration, myocardial infarction, stem cells
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Cardiac Regeneration by Progenitor Cells: What Is It Known as and What Is It Still to Be Known as?
Volume: 7 Issue: 2
Author(s): Massimo F. Piepoli and Alessandro Capucci
Affiliation:
Keywords: Cardiac regeneration, myocardial infarction, stem cells
Abstract: Reperfusion therapy has significantly improved survival and prognosis of patients with acute myocardial infarction. However, the development of heart failure, particularly in patients after a large myocardial damage, remains a major challenge. Cell therapy may provide a novel therapeutic option to modify left ventricular remodeling processes and prevent postinfarction heart failure. Experimental studies have suggested that the infusion of different subsets of bone marrow-derived progenitor cells, circulating endothelial progenitor cells, or tissue-residing stem cells improved neovascularization and cardiac function. Clinical studies at present predominantly used bone marrow mononuclear cells (BMNC) isolated from bone marrow aspirates by density gradient centrifugation. Intracoronary infusion of BMNC significantly increased global or regional ejection fraction and/or reduced infarct size and endsystolic volumes in patients with acute myocardial infarction as demonstrated in initial pilot trials and in randomized studies. We aim to review the existing evidence of the beneficial effect of BMNC infusion as well the controversial issues regarding this promising novel therapeutic approach.
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Piepoli F. Massimo and Capucci Alessandro, Cardiac Regeneration by Progenitor Cells: What Is It Known as and What Is It Still to Be Known as?, Cardiovascular & Hematological Agents in Medicinal Chemistry 2009; 7 (2) . https://dx.doi.org/10.2174/187152509787847100
DOI https://dx.doi.org/10.2174/187152509787847100 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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