Molecular Determinants of Fluoroquinolone Antibacterial Agents Pharmacokinetics

Dominique      Leveque; Francois      Jehl

Abstract

This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.

Keywords: Fluoroquinolone, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, pharmacokinetics, enzymes, drug transporters