Abstract
Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies.
Keywords: Non-canonical peptides, MHC class I, vaccine
Current Pharmaceutical Design
Title: Non-Canonical Peptides Bound to MHC
Volume: 15 Issue: 28
Author(s): Stephanie L. Day, Paul A. Ramsland and Vasso Apostolopoulos
Affiliation:
Keywords: Non-canonical peptides, MHC class I, vaccine
Abstract: Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies.
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Cite this article as:
Day L. Stephanie, Ramsland A. Paul and Apostolopoulos Vasso, Non-Canonical Peptides Bound to MHC, Current Pharmaceutical Design 2009; 15 (28) . https://dx.doi.org/10.2174/138161209789105090
DOI https://dx.doi.org/10.2174/138161209789105090 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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