Abstract
The capacity to rapidly and efficiently elucidate a reliable set of disease specific biomarkers is paramount to enable a future of personalized medicine. High throughput screening methods applied to human clinical samples for the discovery of diagnostic, prognostic, and therapeutic targets address this need. Although the ability to analyze either thousands of markers from one sample or one marker from thousands of samples is the current state of high throughput screening, it would be ideal to have the ability to analyze thousands of markers from thousands of samples to expedite the early discovery phase of biomarkers and their validation. This review summarizes the current state of high throughput screening of tissue specimens and discusses its applications. In addition, the rationale, difficulties, strategies, and development of new technologies to address the need for improved high throughput capabilities are discussed.
Keywords: Tissue, microdissection, high throughput screening, biomarker discovery, biomarker validation, technologies, review
Combinatorial Chemistry & High Throughput Screening
Title: High Throughput Screening of Normal and Neoplastic Tissue Samples
Volume: 13 Issue: 3
Author(s): Heidi S. Erickson, Gallya Gannot, Michael A. Tangrea, Rodrigo F. Chuaqui, John W. Gillespie and Michael R. Emmert-Buck
Affiliation:
Keywords: Tissue, microdissection, high throughput screening, biomarker discovery, biomarker validation, technologies, review
Abstract: The capacity to rapidly and efficiently elucidate a reliable set of disease specific biomarkers is paramount to enable a future of personalized medicine. High throughput screening methods applied to human clinical samples for the discovery of diagnostic, prognostic, and therapeutic targets address this need. Although the ability to analyze either thousands of markers from one sample or one marker from thousands of samples is the current state of high throughput screening, it would be ideal to have the ability to analyze thousands of markers from thousands of samples to expedite the early discovery phase of biomarkers and their validation. This review summarizes the current state of high throughput screening of tissue specimens and discusses its applications. In addition, the rationale, difficulties, strategies, and development of new technologies to address the need for improved high throughput capabilities are discussed.
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Cite this article as:
Erickson S. Heidi, Gannot Gallya, Tangrea A. Michael, Chuaqui F. Rodrigo, Gillespie W. John and Emmert-Buck R. Michael, High Throughput Screening of Normal and Neoplastic Tissue Samples, Combinatorial Chemistry & High Throughput Screening 2010; 13 (3) . https://dx.doi.org/10.2174/138620710790980540
DOI https://dx.doi.org/10.2174/138620710790980540 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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