Abstract
The food-grade bacterium Lactococcus lactis has been extensively investigated during the last two decades as a delivery vector for therapeutic proteins, DNA and vaccine antigens. The bacterium represents a safe, genetically tractable vector capable of producing heterologous therapeutic proteins at mucosal sites. Here we review recent work in which recombinant L. lactis strains have been exploited as agents to treat inflammatory bowel disease, allergy and cancer. We also describe the ability of L. lactis to deliver proteins with adjuvant potential, vaccines and DNA and discuss the therapeutic possibilities of this approach.
Keywords: Lactococcus, vaccine, therapeutic protein, vector, delivery, immunomodulation, IBD
Current Gene Therapy
Title: Lactococcus lactis as a Cell Factory for Delivery of Therapeutic Proteins
Volume: 10 Issue: 1
Author(s): Mohammed Bahey-El-Din, Cormac G.M. Gahan and Brendan T. Griffin
Affiliation:
Keywords: Lactococcus, vaccine, therapeutic protein, vector, delivery, immunomodulation, IBD
Abstract: The food-grade bacterium Lactococcus lactis has been extensively investigated during the last two decades as a delivery vector for therapeutic proteins, DNA and vaccine antigens. The bacterium represents a safe, genetically tractable vector capable of producing heterologous therapeutic proteins at mucosal sites. Here we review recent work in which recombinant L. lactis strains have been exploited as agents to treat inflammatory bowel disease, allergy and cancer. We also describe the ability of L. lactis to deliver proteins with adjuvant potential, vaccines and DNA and discuss the therapeutic possibilities of this approach.
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Cite this article as:
Bahey-El-Din Mohammed, Gahan G.M. Cormac and Griffin T. Brendan, Lactococcus lactis as a Cell Factory for Delivery of Therapeutic Proteins, Current Gene Therapy 2010; 10 (1) . https://dx.doi.org/10.2174/156652310790945557
DOI https://dx.doi.org/10.2174/156652310790945557 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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