Abstract
As proteomics technologies develop, increasing number of membrane-associated proteins specific for cancer cells are being discovered. These proteins are of great interest, particularly because they are rich in targets for antibodies. Amongst them candidate biomarkers for early tumor diagnosis, prognosis and treatment have been detected. The suitability of several membrane-associated proteins as targets for drugs or antibodies has already been tested in preclinical and clinical studies. The results were encouraging in some cases, but not in all. They demonstrate that each type of tumor has its specific “Achilles heel”, and that suitable targets of cancer diagnosis and therapy must be found for each kind of neoplasm. This implies that membrane-associated proteins for each type of tumor cell need to be investigated. This review describes the current technologies of membrane protein characterization in a first part and subsequently summarizes the membrane associated proteins currently being tested as targets for diagnosis and treatment in breast, prostate, thyroid, and colon cancer. Their function will be explained and their role in tumor biology will be discussed.
Keywords: Proteomics, biomarker, thyroid cancer, breast cancer, colorectal cancer, prostate cancer, proteomics technologies, Achilles heel, neoplasm, Helicobacter pylori, papilloma virus, lipid bilayer, eukaryotic cells, carbohydrate moieties, tumorigenesis, malignant cell, Liquid chromatography, mass spectrometry, laser microdissection, isoelectric focusing, cytosolic proteins, 2D electrophoresis, biotinylation, Immunological methods, malignant cells, Paclitaxel, Trastuzuma, Ertumaxomab, heat shock pro-tein 90, R-Flurbiprofen, Ibuprofen, hormone-refractory prostate cancer (HRPC), tumor neovascularization, thyroid stimulating hormone (TSH), thyroid gland, thyrotrophin, radiotherapy, para-follicular, C cells, somatostatin receptor, tyrosine kinases, carcinoembryonic antigen, glycoprotein A33, metastasis, immunoglobulin, glycosylphosphatidylinositol, threonine residues, N-acetyl-glucosamine, hyaluronan, Lapatinib, Neratinib, Sunitinib, Bevacizumab, Cetuximab, Panitumumab, iodine transporters
Current Medicinal Chemistry
Title: Diagnostic and Therapeutic Use of Membrane Proteins in Cancer Cells
Volume: 18 Issue: 2
Author(s): D. Grimm, J. Bauer, J. Pietsch, M. Infanger, J. Eucker, C. Eilles and J. Schoenberger
Affiliation:
Keywords: Proteomics, biomarker, thyroid cancer, breast cancer, colorectal cancer, prostate cancer, proteomics technologies, Achilles heel, neoplasm, Helicobacter pylori, papilloma virus, lipid bilayer, eukaryotic cells, carbohydrate moieties, tumorigenesis, malignant cell, Liquid chromatography, mass spectrometry, laser microdissection, isoelectric focusing, cytosolic proteins, 2D electrophoresis, biotinylation, Immunological methods, malignant cells, Paclitaxel, Trastuzuma, Ertumaxomab, heat shock pro-tein 90, R-Flurbiprofen, Ibuprofen, hormone-refractory prostate cancer (HRPC), tumor neovascularization, thyroid stimulating hormone (TSH), thyroid gland, thyrotrophin, radiotherapy, para-follicular, C cells, somatostatin receptor, tyrosine kinases, carcinoembryonic antigen, glycoprotein A33, metastasis, immunoglobulin, glycosylphosphatidylinositol, threonine residues, N-acetyl-glucosamine, hyaluronan, Lapatinib, Neratinib, Sunitinib, Bevacizumab, Cetuximab, Panitumumab, iodine transporters
Abstract: As proteomics technologies develop, increasing number of membrane-associated proteins specific for cancer cells are being discovered. These proteins are of great interest, particularly because they are rich in targets for antibodies. Amongst them candidate biomarkers for early tumor diagnosis, prognosis and treatment have been detected. The suitability of several membrane-associated proteins as targets for drugs or antibodies has already been tested in preclinical and clinical studies. The results were encouraging in some cases, but not in all. They demonstrate that each type of tumor has its specific “Achilles heel”, and that suitable targets of cancer diagnosis and therapy must be found for each kind of neoplasm. This implies that membrane-associated proteins for each type of tumor cell need to be investigated. This review describes the current technologies of membrane protein characterization in a first part and subsequently summarizes the membrane associated proteins currently being tested as targets for diagnosis and treatment in breast, prostate, thyroid, and colon cancer. Their function will be explained and their role in tumor biology will be discussed.
Export Options
About this article
Cite this article as:
Grimm D., Bauer J., Pietsch J., Infanger M., Eucker J., Eilles C. and Schoenberger J., Diagnostic and Therapeutic Use of Membrane Proteins in Cancer Cells, Current Medicinal Chemistry 2011; 18 (2) . https://dx.doi.org/10.2174/092986711794088344
DOI https://dx.doi.org/10.2174/092986711794088344 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Interplay between Indoleamine 2,3-Dioxygenase 1 (IDO1) and Cyclooxygenase (COX)-2 In Chronic Inflammation and Cancer
Current Medicinal Chemistry Adverse Effects of Statins - Mechanisms and Consequences
Current Drug Safety Current Therapeutic Leads for the Treatment of Melanoma: Targeted Immunotherapy in the Post-genomic Era
Current Molecular Pharmacology Tumor Initiating Cells
Current Pharmaceutical Biotechnology Nuclear Hormone Receptors and Female Reproduction
Current Molecular Medicine Targeting the Fibroblast Growth Factor Receptors for the Treatment of Cancer
Anti-Cancer Agents in Medicinal Chemistry Mitochondria: A Target for Neuroprotective Interventions in Cerebral Ischemia-Reperfusion
Current Pharmaceutical Design miRNAs Highlights in Stem and Cancer Cells
Mini-Reviews in Medicinal Chemistry Recent Advances in the Research and Development of B-Raf Inhibitors
Current Medicinal Chemistry The Human Indoleamine 2,3-Dioxygenase Gene and Related Human Genes
Current Drug Metabolism New Perspectives Regarding Anaplastic Thyroid Carcinoma Approach Improvement
Endocrine, Metabolic & Immune Disorders - Drug Targets Emerging Therapeutic Approaches Based on Nanotechnology for the Treatment of Diseases Associated with Telomere Dysfunction
Mini-Reviews in Medicinal Chemistry FAK and p53 Protein Interactions
Anti-Cancer Agents in Medicinal Chemistry Regulatory T Cells and Allergic Disease
Inflammation & Allergy - Drug Targets (Discontinued) Novel Study Designs in Precision Medicine – Basket, Umbrella and Platform Trials
Current Reviews in Clinical and Experimental Pharmacology Relationship Between Vitamin D Deficiency and Chronic Low Back Pain in Postmenopausal Women
Current Rheumatology Reviews Preface
MicroRNA The Janus Face of Cathelicidin in Tumorigenesis
Current Medicinal Chemistry The Role of 3D Pharmacophore Mapping Based Virtual Screening for Identification of Novel Anticancer Agents: An Overview
Current Topics in Medicinal Chemistry Modulation of Apoptosis: New Opportunities for Drug Discovery to Treat Autoimmune Thyroiditis
Recent Patents on Inflammation & Allergy Drug Discovery