Abstract
Acarbose is a clinically useful drug for the treatment of type II insulin-independent diabetes as a hypoglycemic agent. This minireview summarized detection and separation methods for the analysis and determination of anti-diabetes drug acarbose and its structural analogs, including HPLC, enzyme-based biosensor and capillary electrophoresis. Besides the protocol, principle behind each technique is presented together with its strengths and weaknesses. Finally, we analyze the future trends in the acarbose analysis.
Keywords: Diabetes, Acarbose, Analysis, Liquid chromatography, Capillary electrophoresis, Biosensor, α-glucosidase Inhibitor, Non-Insulin-Dependent Diabetes Mellitus (NIDDM), Refractive Index Detection (RID), Evaporative Light Scattering Detection (ELSD), Normal Phase Liquid Chromatography (NPLC)
Current Pharmaceutical Analysis
Title: Analysis and Determination of Anti-diabetes Drug Acarbose and its Structural Analogs
Volume: 7 Issue: 1
Author(s): Ya-Jun Wang, Yu-Guo Zheng, Ya-Ping Xue, Yuan-Shan Wang and Yin-Chu Shen
Affiliation:
Keywords: Diabetes, Acarbose, Analysis, Liquid chromatography, Capillary electrophoresis, Biosensor, α-glucosidase Inhibitor, Non-Insulin-Dependent Diabetes Mellitus (NIDDM), Refractive Index Detection (RID), Evaporative Light Scattering Detection (ELSD), Normal Phase Liquid Chromatography (NPLC)
Abstract: Acarbose is a clinically useful drug for the treatment of type II insulin-independent diabetes as a hypoglycemic agent. This minireview summarized detection and separation methods for the analysis and determination of anti-diabetes drug acarbose and its structural analogs, including HPLC, enzyme-based biosensor and capillary electrophoresis. Besides the protocol, principle behind each technique is presented together with its strengths and weaknesses. Finally, we analyze the future trends in the acarbose analysis.
Export Options
About this article
Cite this article as:
Wang Ya-Jun, Zheng Yu-Guo, Xue Ya-Ping, Wang Yuan-Shan and Shen Yin-Chu, Analysis and Determination of Anti-diabetes Drug Acarbose and its Structural Analogs, Current Pharmaceutical Analysis 2011; 7 (1) . https://dx.doi.org/10.2174/157341211794708721
DOI https://dx.doi.org/10.2174/157341211794708721 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Adenosine, Ketogenic Diet and Epilepsy: The Emerging Therapeutic Relationship Between Metabolism and Brain Activity
Current Neuropharmacology Self-Care in Adults with Type 2 Diabetes Mellitus: A Systematic Review
Current Diabetes Reviews Effects of Long-Term Intraperitoneal Injection of Thyrotropin-Releasing Hormone (TRH) on Aging- and Obesity-Related Changes in Body Weight, Lipid Metabolism, and Thyroid Functions
Current Aging Science Metformin: A Rising Star to Fight the Epithelial Mesenchymal Transition in Oncology
Anti-Cancer Agents in Medicinal Chemistry Biomarkers Linking PCB Exposure and Obesity
Current Pharmaceutical Biotechnology A Systematic Review and Meta-analysis on Efficacy of Exercise on Posture and Balance in Patients Suffering from Diabetic Neuropathy
Current Diabetes Reviews The Epidemiology of Cardiovascular Disease in Adults with Type 1 Diabetes
Current Diabetes Reviews Prevalence of Anxiety During Pregnancy in Women with Previous Spontaneous Abortions
Current Women`s Health Reviews Editorial: Natural Compounds and Their Derivatives as a Source of Promising Drugs for Diabetes and Insulin Resistance
Current Drug Targets Will Antirheumatic Treatment Improve Cardiovascular Outcomes in Patients with Rheumatoid Arthritis?
Current Pharmaceutical Design Editorial (Hot Topic: Hypertension: A Serious Complication in Pregnancy)
Current Hypertension Reviews Vitamin D Deficiency and Oxidative Stress in Type 2 Diabetic Population of India
Cardiovascular & Hematological Agents in Medicinal Chemistry Withdrawal Notice: Characterization of Glyoxal Modified LDL: Role in the Generation of Circulating Autoantibodies in Type 2 Diabetes Mellitus and Coronary Artery Disease
Current Drug Targets The Impact of Maternal Voice on the Fetus: A Systematic Review
Current Women`s Health Reviews New Pharmacological Perspectives and Therapeutic Potential of PPAR-γ Agonists
Current Pharmaceutical Design Enhancing Central Nervous System Endogenous GLP-1 Receptor Pathways for Intervention in Alzheimers Disease
Current Alzheimer Research An Arylidene-Thiazolidinedione Derivative, GPU-4, without PPARγ Activation, Reduces Retinal Neovascularization
Current Neurovascular Research Association of Thrombospondin-1 (N700S) and Thrombospond in-4 (A387P) Gene Polymorphisms with the Incidence of Acute Myocardial Infarction in Egyptians
Current Pharmaceutical Biotechnology Lead Finding from Selected Flavonoids with Antiviral (SARS-CoV-2) Potentials Against COVID-19: An In-silico Evaluation
Combinatorial Chemistry & High Throughput Screening Signal Transduction Therapy of Diabetic Vascular Complication
Current Signal Transduction Therapy