Abstract
Mast cell and sensory nerve relationships fall into three categories: proximity, communication and a shared fate. Mast cells are found in all tissues of the human body, especially located closely to nerves. Mast-nerve membrane to membrane contact is a highly common configuration. This should be by design rather than by accident since such spatial distributions generally indicate a functional relationship. Mast cells associated to sensory nerves contain abundant neuropeptides and also a range of neuropeptide receptors enabling nerve to mast cell, mast cell to nerve and reciprocal communications which form the basis of neuroimmune interfacing. Wondering about the possible effects of this intimacy and communication potential on several physiological and pathophysiological events, specifically on diseases with low success rates of therapy and mysterious mechanisms, scientists have uncovered many aspects of mast-nerve interactions. In light of these studies, from a focal point between the nervous and immune systems, mast cells highlight the concept of collaboration as an indispensable building block of the neuroimmune system.
Keywords: CGRP, Neurogenic inflammation, Neuropeptide, Mast cell, Sensory nerve, Substance P, Tumor necrosis factor (TNF), Peptidergic nerve, Clostridium difficile, Atopic dermaititis (AD)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Anatomical and Functional Relationships Between Sensory Nerves and Mast Cells
Volume: 10 Issue: 1
Author(s): Fatma Tore and Nese Tuncel
Affiliation:
Keywords: CGRP, Neurogenic inflammation, Neuropeptide, Mast cell, Sensory nerve, Substance P, Tumor necrosis factor (TNF), Peptidergic nerve, Clostridium difficile, Atopic dermaititis (AD)
Abstract: Mast cell and sensory nerve relationships fall into three categories: proximity, communication and a shared fate. Mast cells are found in all tissues of the human body, especially located closely to nerves. Mast-nerve membrane to membrane contact is a highly common configuration. This should be by design rather than by accident since such spatial distributions generally indicate a functional relationship. Mast cells associated to sensory nerves contain abundant neuropeptides and also a range of neuropeptide receptors enabling nerve to mast cell, mast cell to nerve and reciprocal communications which form the basis of neuroimmune interfacing. Wondering about the possible effects of this intimacy and communication potential on several physiological and pathophysiological events, specifically on diseases with low success rates of therapy and mysterious mechanisms, scientists have uncovered many aspects of mast-nerve interactions. In light of these studies, from a focal point between the nervous and immune systems, mast cells highlight the concept of collaboration as an indispensable building block of the neuroimmune system.
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Cite this article as:
Tore Fatma and Tuncel Nese, Anatomical and Functional Relationships Between Sensory Nerves and Mast Cells, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (1) . https://dx.doi.org/10.2174/187152311795325550
DOI https://dx.doi.org/10.2174/187152311795325550 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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