Abstract
Invasion and metastasis, the hallmark of malignant tumor, is the main reason for the clinical death of most cancer patients. Tumor invasion and metastasis are complex, multi-step biochemical processes, which involve cell detachment, invasion, migration, intravasation and circulation, implantation, angiogenesis and proliferation. Therefore, how to prevent tumor metastasis has been the biggest challenge in cancer chemotherapy. In recent years, many natural products have been found to have anti-invasive and anti-metastatic activities. In this paper, these natural compounds are classified as polyphenols, terpenoids, alkaloids, steroids and saponins, saccharides, macrolides, amides and others, their anti-invasive and anti-metastatic activities as well as their biological targets are reviewed.
Keywords: Anti-invasive, anti-metastatic, cancer, invasion, metastasis, natural products, targets, tumor, intravasation, angiogenesis, proliferation, polyphenols
Current Medicinal Chemistry
Title: Natural Products as Anti-Invasive and Anti-Metastatic Agents
Volume: 18 Issue: 6
Author(s): Y.-L. Jiang and Z.-P. Liu
Affiliation:
Keywords: Anti-invasive, anti-metastatic, cancer, invasion, metastasis, natural products, targets, tumor, intravasation, angiogenesis, proliferation, polyphenols
Abstract: Invasion and metastasis, the hallmark of malignant tumor, is the main reason for the clinical death of most cancer patients. Tumor invasion and metastasis are complex, multi-step biochemical processes, which involve cell detachment, invasion, migration, intravasation and circulation, implantation, angiogenesis and proliferation. Therefore, how to prevent tumor metastasis has been the biggest challenge in cancer chemotherapy. In recent years, many natural products have been found to have anti-invasive and anti-metastatic activities. In this paper, these natural compounds are classified as polyphenols, terpenoids, alkaloids, steroids and saponins, saccharides, macrolides, amides and others, their anti-invasive and anti-metastatic activities as well as their biological targets are reviewed.
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Cite this article as:
Jiang Y.-L. and Liu Z.-P., Natural Products as Anti-Invasive and Anti-Metastatic Agents, Current Medicinal Chemistry 2011; 18 (6) . https://dx.doi.org/10.2174/092986711794927711
DOI https://dx.doi.org/10.2174/092986711794927711 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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