Abstract
The Forkhead Box O (Foxo) proteins represent an evolutionarily conserved family of transcription factors that play an important role in regulating processes including metabolism, longevity, and cell death/survival. How is it that a single transcription factor can initiate such divergent cellular responses? We will review the evidence that specific patterns of post-translational modifications play a key role in directing Foxo into various transcriptional readouts. This regulation appears to take on a two tiered regulatory model; with a group of well defined post-translational modifications regulating nuclear localization and transcriptional activity while a second set of modifications regulate the transcriptional specificity of Foxo
Keywords: Foxo, post-translational modifications, phosphorylation, acetylation, ubiquitination, Drosophila, Caenorhabditis, Nuclear localization sequence, DYRK1A, MST1, AMPK, SIRT1, MDM2, USP7
Current Drug Targets
Title: Regulation of Foxo-Dependent Transcription by Post-Translational Modifications
Volume: 12 Issue: 9
Author(s): Marco Boccitto and Robert G. Kalb
Affiliation:
Keywords: Foxo, post-translational modifications, phosphorylation, acetylation, ubiquitination, Drosophila, Caenorhabditis, Nuclear localization sequence, DYRK1A, MST1, AMPK, SIRT1, MDM2, USP7
Abstract: The Forkhead Box O (Foxo) proteins represent an evolutionarily conserved family of transcription factors that play an important role in regulating processes including metabolism, longevity, and cell death/survival. How is it that a single transcription factor can initiate such divergent cellular responses? We will review the evidence that specific patterns of post-translational modifications play a key role in directing Foxo into various transcriptional readouts. This regulation appears to take on a two tiered regulatory model; with a group of well defined post-translational modifications regulating nuclear localization and transcriptional activity while a second set of modifications regulate the transcriptional specificity of Foxo
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Cite this article as:
Boccitto Marco and G. Kalb Robert, Regulation of Foxo-Dependent Transcription by Post-Translational Modifications, Current Drug Targets 2011; 12 (9) . https://dx.doi.org/10.2174/138945011796150316
DOI https://dx.doi.org/10.2174/138945011796150316 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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