Abstract
Nanoparticles based on poly(propylene succinate) copolymers with poly(ethyleneglycol) (PPSu-PEG) were prepared and evaluated in vitro for their potential for a more selective delivery of cisplatin to tumors using local hyperthermia. The copolymers were synthesized through one-pot melt-polymerization under vacuum. Their thermal properties were investigated using DSC. PPSu-PEG nanoparticles loaded with cisplatin were prepared by a double emulsion method. Their colloidal stability, drug release properties, and in vitro anticancer activity were assessed. The m.p. of the synthesized PPSu-PEG copolymers ranged between 40-45 °C. The PPSu-PEG nanoparticles were stable in aqueous media with high salt concentrations. The average size of the different compositions of the PPSu- PEG nanoparticles loaded with cisplatin ranged between 77 and 126 nm and all compositions exhibited low negative ζ-potential values. The PPSU-PEG/cisplatin nanoparticles released cisplatin much faster at 42 ° C than at 37 ° C and exhibited comparable to free cisplatin cytotoxicity against HT 29 cells, which was increased when the incubation temperature was increased from 37 ° C to 42 ° C. The results justify further investigation of the potential of PPSu-PEG copolymers for the development of temperature-sensitive, targetable cisplatin nanocarriers.
Keywords: Cisplatin, cytotoxicity, hyperthermia, nanoparticles, poly(propylene succinate-poly(ethyleneglycol)
Current Nanoscience
Title: PPSu-PEG Copolymers and their Application in the Preparation of Cisplatin-loaded Nanoparticles
Volume: 7 Issue: 4
Author(s): Spiridoula Kyriakopoulou, George Mattheolabakis, Sofia Papadimitriou, Evangelos Karavas, Dimitrios Bikiaris and Konstantinos Avgoustakis
Affiliation:
Keywords: Cisplatin, cytotoxicity, hyperthermia, nanoparticles, poly(propylene succinate-poly(ethyleneglycol)
Abstract: Nanoparticles based on poly(propylene succinate) copolymers with poly(ethyleneglycol) (PPSu-PEG) were prepared and evaluated in vitro for their potential for a more selective delivery of cisplatin to tumors using local hyperthermia. The copolymers were synthesized through one-pot melt-polymerization under vacuum. Their thermal properties were investigated using DSC. PPSu-PEG nanoparticles loaded with cisplatin were prepared by a double emulsion method. Their colloidal stability, drug release properties, and in vitro anticancer activity were assessed. The m.p. of the synthesized PPSu-PEG copolymers ranged between 40-45 °C. The PPSu-PEG nanoparticles were stable in aqueous media with high salt concentrations. The average size of the different compositions of the PPSu- PEG nanoparticles loaded with cisplatin ranged between 77 and 126 nm and all compositions exhibited low negative ζ-potential values. The PPSU-PEG/cisplatin nanoparticles released cisplatin much faster at 42 ° C than at 37 ° C and exhibited comparable to free cisplatin cytotoxicity against HT 29 cells, which was increased when the incubation temperature was increased from 37 ° C to 42 ° C. The results justify further investigation of the potential of PPSu-PEG copolymers for the development of temperature-sensitive, targetable cisplatin nanocarriers.
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Cite this article as:
Kyriakopoulou Spiridoula, Mattheolabakis George, Papadimitriou Sofia, Karavas Evangelos, Bikiaris Dimitrios and Avgoustakis Konstantinos, PPSu-PEG Copolymers and their Application in the Preparation of Cisplatin-loaded Nanoparticles, Current Nanoscience 2011; 7 (4) . https://dx.doi.org/10.2174/157341311796196880
DOI https://dx.doi.org/10.2174/157341311796196880 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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