Abstract
While lifestyle modifications and metformin are the cornerstone of the initial management of type 2 diabetes mellitus, there is an increasing array of second and third-line pharmacological agents for this condition. These include sulphonylureas, insulin, thiazolidinediones and alpha-glucosidase inhibitors, with the more recent addition of glucagon- like peptide-1 agonists, dipeptidyl peptidase-IV inhibitors and pramlintide. Moreover, insulin analogues that better simulate endogenous insulin secretion have been developed. This review aims to provide an update on the current pharmacological management of type 2 diabetes mellitus, and to highlight the benefits and limitations of each treatment.
Keywords: Type 2 diabetes mellitus, Insulin, Thiazolidinediones, Sulphonylurea, Metformin, Glucagon-like peptide-1, Dipeptidyl peptidase-IV inhibitor, Bromocriptine, Alpha glucosidase inhibitor, Colesevelam
Current Diabetes Reviews
Title: Pharmacological Management of Type 2 Diabetes Mellitus: An Update
Volume: 7 Issue: 6
Author(s): Samer El-Kaissi and Suphia Sherbeeni
Affiliation:
Keywords: Type 2 diabetes mellitus, Insulin, Thiazolidinediones, Sulphonylurea, Metformin, Glucagon-like peptide-1, Dipeptidyl peptidase-IV inhibitor, Bromocriptine, Alpha glucosidase inhibitor, Colesevelam
Abstract: While lifestyle modifications and metformin are the cornerstone of the initial management of type 2 diabetes mellitus, there is an increasing array of second and third-line pharmacological agents for this condition. These include sulphonylureas, insulin, thiazolidinediones and alpha-glucosidase inhibitors, with the more recent addition of glucagon- like peptide-1 agonists, dipeptidyl peptidase-IV inhibitors and pramlintide. Moreover, insulin analogues that better simulate endogenous insulin secretion have been developed. This review aims to provide an update on the current pharmacological management of type 2 diabetes mellitus, and to highlight the benefits and limitations of each treatment.
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Cite this article as:
El-Kaissi Samer and Sherbeeni Suphia, Pharmacological Management of Type 2 Diabetes Mellitus: An Update, Current Diabetes Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339911797579160
DOI https://dx.doi.org/10.2174/157339911797579160 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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