Abstract
A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene- 3,17β-diols.
Keywords: thermal dehydration, conjugate addition, steroids, Estranes
Letters in Organic Chemistry
Title: Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols
Volume: 3 Issue: 3
Author(s): Thies Thiemann, G. Ribeiro M. and Maria C. d. Neves Oliveira
Affiliation:
Keywords: thermal dehydration, conjugate addition, steroids, Estranes
Abstract: A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene- 3,17β-diols.
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Cite this article as:
Thiemann Thies, M. Ribeiro G. and Neves Oliveira C. d. Maria, Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols, Letters in Organic Chemistry 2006; 3 (3) . https://dx.doi.org/10.2174/157017806775789796
DOI https://dx.doi.org/10.2174/157017806775789796 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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