Abstract
Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.
Keywords: Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species
Mini-Reviews in Medicinal Chemistry
Title: New Insights into the Regulation of Liver Inflammation and Oxidative Stress
Volume: 6 Issue: 12
Author(s): Natalia Ferre and Joan Claria
Affiliation:
Keywords: Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species
Abstract: Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.
Export Options
About this article
Cite this article as:
Ferre Natalia and Claria Joan, New Insights into the Regulation of Liver Inflammation and Oxidative Stress, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778993049
DOI https://dx.doi.org/10.2174/138955706778993049 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Natural Products with Antiangiogenic and Antivasculogenic Mimicry Activity
Mini-Reviews in Medicinal Chemistry Fc Receptors as Potential Targets for the Treatment of Allergy, Autoimmune Disease and Cancer
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Reduction of Doxorubicin-Induced Cardiotoxicity Using Nanocarriers: A Review
Current Drug Metabolism Animal Models of Lung Fibrosis
Current Respiratory Medicine Reviews Prevalence of Anti-nuclear and Anti-phospholipid Antibodies in an Egyptian Cohort with Schizophrenia: A Case-control Study
Current Rheumatology Reviews HCV and Autoimmunity
Current Pharmaceutical Design A UPLC-MS/MS Method for Simultaneous Determination of Six Bioactive Compounds in Rat Plasma, and its Application to Pharmacokinetic Studies of Naoshuantong Granule in Rats
Current Pharmaceutical Analysis Stem Cell Aging and Age-Related Cardiovascular Disease: Perspectives of Treatment by Ex-vivo Stem Cell Rejuvenation
Current Drug Targets TNFα as Therapeutic Target: New Drugs, More Applications
Current Drug Targets - Inflammation & Allergy Evolving Insights into the Pathophysiology of Diabetic Neuropathy: Implications of Malfunctioning Glia and Discovery of Novel Therapeutic Targets
Current Pharmaceutical Design Mapping Myeloperoxidase to Identify its Promiscuity Properties Using Docking and Molecular Dynamics Simulations
Current Pharmaceutical Design The Use of Cyclosporine in Respiratory Diseases
Current Respiratory Medicine Reviews Anti-angiogenic Treatment in Metastatic Colorectal Cancer: Current Issues and Future Aims
Current Cancer Therapy Reviews Nimodipine Reappraised: An Old Drug With a Future
Current Neuropharmacology Pathological Features of Antibody-Mediated Rejection
Current Drug Targets - Cardiovascular & Hematological Disorders The Effect of Phase Transition Temperature on Therapeutic Efficacy of Liposomal Bortezomib
Anti-Cancer Agents in Medicinal Chemistry Acute Severe Arterial Hypertension: Therapeutic Options
Current Drug Targets Signs and Related Mechanisms of Ethanol Hepatotoxicity
Current Drug Abuse Reviews Alpha-1 Antitrypsin Deficiency: Current Perspective from Genetics to Diagnosis and Therapeutic Approaches
Current Medicinal Chemistry Interstitial Lung Disease in Rheumatoid Arthritis
Current Rheumatology Reviews