Inhibitors of the Chemokine Receptor CXCR4: Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis

Title: Inhibitors of the Chemokine Receptor CXCR4: Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis

Volume: 4 Issue: 1

Author(s): Hiroshi Tsutsumi, Hirokazu Tamamura and Nobutaka Fujii

Affiliation:

Keywords: Cancer metastasis, Chemokine receptor, HIV infection, Leukemia cell progression, Low molecular weight CXCR4 antagonist, Rheumatoid arthritis

Abstract: The interaction between the chemokine, CXCL12 and its receptor, CXCR4 is known to be involved in several intractable disease processes, including HIV infection, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis. It is conjectured that this interaction may be an important therapeutic target in all of these diseases, and various CXCR4 antagonists have been proposed as potential drugs. This article describes the development in our laboratory of a number of specific CXCR4 antagonists.

Cite this article as:

Tsutsumi Hiroshi, Tamamura Hirokazu and Fujii Nobutaka, Inhibitors of the Chemokine Receptor CXCR4: Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis, Letters in Drug Design & Discovery 2007; 4 (1) . https://dx.doi.org/10.2174/157018007778992900