Abstract
We report herein the study of the cleavage fragments generated by autoproteolysis of the St. Louis encephalitis virus recombinant protease. The cleavage sites leading to truncated forms were identified by microsequencing, which revealed an unexpected altered specificity of the recombinant proteinase towards unusual sequences.
Keywords: Altered specificity, autoproteolysis, flavivirin, NS3, trypsin-like serine protease
Protein & Peptide Letters
Title: Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis
Volume: 14 Issue: 1
Author(s): Boris A.M. Pastorino, Christophe N. Peyrefitte, Marc Grandadam, Regine Lebrun, Danielle Moinier, Dominique Rolland, Hugues J. Tolou and Mael Bessaud
Affiliation:
Keywords: Altered specificity, autoproteolysis, flavivirin, NS3, trypsin-like serine protease
Abstract: We report herein the study of the cleavage fragments generated by autoproteolysis of the St. Louis encephalitis virus recombinant protease. The cleavage sites leading to truncated forms were identified by microsequencing, which revealed an unexpected altered specificity of the recombinant proteinase towards unusual sequences.
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Cite this article as:
Pastorino A.M. Boris, Peyrefitte N. Christophe, Grandadam Marc, Lebrun Regine, Moinier Danielle, Rolland Dominique, Tolou J. Hugues and Bessaud Mael, Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis, Protein & Peptide Letters 2007; 14 (1) . https://dx.doi.org/10.2174/092986607779117146
DOI https://dx.doi.org/10.2174/092986607779117146 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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