Abstract
In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ETAh and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6- trimethylphenyl)benzamide (23) was the most interesting.
Keywords: Hypertension, Endothelins, G protein-coupled receptors, ET receptors, Benzenesulfonamides, Binding properties
Letters in Drug Design & Discovery
Title: Synthesis and Binding Properties of New Endothelin Receptor Ligands
Volume: 4 Issue: 3
Author(s): Maria Modica, Loredana Salerno, Valeria Pittala, Giuseppe Romeo, Mariangela Siracusa, Ilario Mereghetti, Alfredo Cagnotto and Tiziana Mennini
Affiliation:
Keywords: Hypertension, Endothelins, G protein-coupled receptors, ET receptors, Benzenesulfonamides, Binding properties
Abstract: In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ETAh and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6- trimethylphenyl)benzamide (23) was the most interesting.
Export Options
About this article
Cite this article as:
Modica Maria, Salerno Loredana, Pittala Valeria, Romeo Giuseppe, Siracusa Mariangela, Mereghetti Ilario, Cagnotto Alfredo and Mennini Tiziana, Synthesis and Binding Properties of New Endothelin Receptor Ligands, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077426
DOI https://dx.doi.org/10.2174/157018007780077426 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Apolipoprotein E Knockout Models
Current Pharmaceutical Design SGLT-2 inhibitors in Diabetic Kidney Disease: What Lies Behind their Renoprotective Properties?
Current Medicinal Chemistry Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium
Current Pharmaceutical Design Pharmacological Strategies Against Glucocorticoid-mediated Brain Damage During Chronic Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Renin-Angiotensin-Aldosterone System in Autosomal Dominant Polycystic Kidney Disease
Current Hypertension Reviews Active Metabolites Resulting from Decarboxylation, Reduction and Ester Hydrolysis of Parent Drugs
Current Drug Metabolism Physiological Effect and Therapeutic Application of Alpha Lipoic Acid
Current Medicinal Chemistry Enhanced Proinflammatory State and Autoimmune Activation: a Breakthrough to Understanding Chronic Diseases
Current Pharmaceutical Design Blood Pressure Management in Acute Stroke
Current Hypertension Reviews Interstitial Lung Disease in Sjogrens Syndrome
Current Rheumatology Reviews Mediterranean Diet and Low-grade Subclinical Inflammation: The Moli-sani Study
Endocrine, Metabolic & Immune Disorders - Drug Targets Role of Endogenous Androgen Against Insulin Resistance and Athero-sclerosis in Men with Type 2 Diabetes
Current Diabetes Reviews Aging Blunts Ischemic-Preconditioning-Induced Neuroprotection Following Transient Global Ischemia in Rats
Current Neurovascular Research Anti-Angiogenic Approaches to Malignant Gliomas
Current Cancer Drug Targets Aorta Remodeling Due to Stretch or Turbulent Flow/Low Wall Shear Stress: Distinctly Different Biological Phenomena?
Current Cardiology Reviews Bile Acids and Farnesoid X Receptor: Novel Target for the Treatment of Diabetic Cardiomyopathy
Current Protein & Peptide Science Soy Isoflavones and Cardiovascular Health: An Update
Current Nutrition & Food Science Nonfasting Hyperlipidemia and Cardiovascular Disease
Current Drug Targets Strategies and Techniques for Multi-Component Drug Design from Medicinal Herbs and Traditional Chinese Medicine
Current Topics in Medicinal Chemistry Infant Breast-Feeding and Suppression of Biomarkers of Future Cardiovascular Disease
Current Nutrition & Food Science